Publication:
Apoptosis, toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens

Simple item page
dc.contributor.authorMartínez, Isidoro
dc.contributor.authorOliveros, Juan C.
dc.contributor.authorCuesta, Isabel
dc.contributor.authorBarrera, Jorge de la
dc.contributor.authorAusina, Vicente
dc.contributor.authorCasals, Cristina
dc.contributor.authorLorenzo, Alba de
dc.contributor.authorGarcía, Ernesto
dc.contributor.authorGarcía Fojeda, Belén
dc.contributor.authorGarmendia García, Juncal
dc.contributor.authorGonzález Nicolau, Mar
dc.contributor.authorLacoma, Alicia
dc.contributor.authorMenéndez, Margarita
dc.contributor.authorMoranta, David
dc.contributor.authorNieto, Amelia
dc.contributor.authorOrtín, Juan
dc.contributor.authorPérez González, Alicia
dc.contributor.authorPrat, Cristina
dc.contributor.authorRamos Sevillano, Elisa
dc.contributor.authorRegueiro, Verónica
dc.contributor.authorRodríguez Frandsen, Ariel
dc.contributor.authorSolís, Dolores
dc.contributor.authorYuste, José R.
dc.contributor.authorBengoechea Alonso, José Antonio
dc.contributor.authorMelero, José A.
dc.contributor.departmentIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes_ES
dc.date.accessioned2018-09-04T06:43:47Z
dc.date.available2018-09-04T06:43:47Z
dc.date.issued2017
dc.description.abstractLower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.en
dc.description.sponsorshipThe authors gratefully acknowledge financial support from the “CIBER de Enfermedades Respiratorias” (CIBERES), an initiative of the “Instituto de Salud Carlos III” (ISCIII), Spain. Research activities in the participating laboratories received further funding from the following sources: Centro Nacional de Microbiología, ISCIII, PI15CIII/00024 and MINECO (SAF2015- 67033-R); Centro Nacional de Biotecnología, MINECO (BFU2014-57797-R); Hospital Universitari Germans Trias I Pujol, Spanish Society of Pneumology and Thoracic Surgery (SEPAR 054/2011); Departamento de Bioquímica y Biología Molecular I, MINECO (SAF2015-65307-R); Centro de Investigaciones Biológicas, MINECO (SAF2012-39444-C01/02); Fundación de Investigación Sanitaria de las Islas Baleares, MINECO (SAF2012-39841); Instituto de Agrobiotecnología, MINECO (SAF2015-66520-R); Instituto de Química Física Rocasolano, MINECO (BFU2015-70052-R) and the Marie Curie Initial Training Network GLYCOPHARM (PITN-GA- 2012-317297). Subprograma Estatal de Formación (BES-2013- 065355).en
dc.format.extent13 p.
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.doi10.3389/fmicb.2017.00276
dc.identifier.issn1664-302X (Electronic)
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/30433
dc.language.isoengen
dc.publisherFrontiers Mediaen
dc.relation.ispartofFrontiers in Microbiology, 8:276en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2015-67033-R/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//BFU2014-57797-R/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2015-65307-R/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2012-39444-C02-02/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2012-39841/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2015-66520-R/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//BFU2015-70052-R/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//SAF2012-39875-C02-01/ES/en
dc.relation.publisherversionhttps://doi.org/10.3389/fmicb.2017.00276
dc.rights© 2017 Martínez, Oliveros, Cuesta, de la Barrera, Ausina, Casals, de Lorenzo, García, García-Fojeda, Garmendia, González-Nicolau, Lacoma, Menéndez, Moranta, Nieto, Ortín, Pérez-González, Prat, Ramos-Sevillano, Regueiro, Rodriguez-Frandsen, Solís, Yuste, Bengoechea and Melero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectRespiratory pathogensen
dc.subjectHost responseen
dc.subjectCore of up-regulated genesen
dc.subjectBacterial infectionsen
dc.subjectViral infectionsen
dc.titleApoptosis, toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogensen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
17_Martinez_Apoptosis.pdf
Size:
2.17 MB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
17_MaterialComplementario.zip
Size:
19.04 MB
Format:
ZIP
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista IdAB - IdAB Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak