Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis
| dc.contributor.author | Hernández-López, Patricia | |
| dc.contributor.author | Cilla, Myriam | |
| dc.contributor.author | Martínez, Miguel Ángel | |
| dc.contributor.author | Peña, Estefanía | |
| dc.contributor.author | Malvè, Mauro | |
| dc.contributor.department | Ingeniería | es_ES |
| dc.contributor.department | Ingeniaritza | eu |
| dc.date.accessioned | 2024-10-09T11:25:47Z | |
| dc.date.available | 2024-10-09T11:25:47Z | |
| dc.date.issued | 2024 | |
| dc.date.updated | 2024-10-09T11:18:19Z | |
| dc.description.abstract | Background and objective: in this work, the analysis of the importance of hemodynamic updates on a mechanobiological model of atheroma plaque formation is proposed. Methods: for that, we use an idealized and axisymmetric model of carotid artery. In addition, the behavior of endothelial cells depending on hemodynamical changes is analyzed too. A total of three computational simulations are carried out and their results are compared: an uncoupled model and two models that consider the opposite behavior of endothelial cells caused by hemodynamic changes. The model considers transient blood flow using the Navier-Stokes equation. Plasma flow across the endothelium is determined with Darcy's law and the Kedem-Katchalsky equations, considering the three-pore model, which is also employed for the flow of substances across the endothelium. The behavior of the considered substances in the arterial wall is modeled with convection¿diffusion¿reaction equations, and the arterial wall is modeled as a hyperelastic Yeoh's material. Results: significant variations are noted in both the morphology and stenosis ratio of the plaques when comparing the uncoupled model to the two models incorporating updates for geometry and hemodynamic stimuli. Besides, the phenomenon of double-stenosis is naturally reproduced in the models that consider both geometric and hemodynamical changes due to plaque growth, whereas it cannot be predicted in the uncoupled model. Conclusions: the findings indicate that integrating the plaque growth model with geometric and hemodynamic settings is essential in determining the ultimate shape and dimensions of the carotid plaque. | en |
| dc.description.sponsorship | Support was obtained from the Spanish Ministry of Science and Technology through the research projects PID2019-107517RB-I00 and PID2022-140219OB-I00 and financial support to P. Hernández-López from the grant BES-2017-080239, and the regional Government of Aragón support for the funding of the research project T24-20R. Myriam Cilla is supported by Grant Ramón Cajal grant 171562 funded by MICIU/AEI/ 10.13039/501100011033 and the European Social Fund Plus (FSE+) . M. Malvé is supported by grant PID2021-125731OB-C31 from the Spanish Ministry of Science and Innovation MCIN/AEI/10.13039/501100011033/ and FEDER ("Away to build Europe").; The authors thank the research support from the CIBER initiative, whose actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund . | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Hernández-López, P., Cilla, M., Martínez, M. A., Peña, E., Malvè, M. (2024). Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis. Computer Methods and Programs in Biomedicine, 254, 1-17. https://doi.org/10.1016/j.cmpb.2024.108296. | |
| dc.identifier.doi | 10.1016/j.cmpb.2024.108296 | |
| dc.identifier.issn | 0169-2607 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/52131 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartof | Computer Methods and Programs in Biomedicine (2024), vol. 254, 108296 | |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107517RB-I00/ES/ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-140219OB-I00/ES/ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-125731OB-C31/ES/ | |
| dc.relation.publisherversion | https://doi.org/10.1016/j.cmpb.2024.108296 | |
| dc.rights | © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC license. | |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
| dc.subject | 2D-axisymmetric model | en |
| dc.subject | Atherosclerosis | en |
| dc.subject | Carotid artery | en |
| dc.subject | Double stenosis phenomenon | en |
| dc.subject | Geometry and hemodynamic changes | en |
| dc.subject | Three pore model | en |
| dc.title | Impact of geometric and hemodynamic changes on a mechanobiological model of atherosclerosis | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | aa62429b-fef0-4a2c-9d96-43dbf7f63675 | |
| relation.isAuthorOfPublication.latestForDiscovery | aa62429b-fef0-4a2c-9d96-43dbf7f63675 |