Space-time analysis of ovarian cancer mortality rates by age groups in Spanish provinces (1989-2015)
| dc.contributor.author | Trandafir, Paula Camelia | |
| dc.contributor.author | Adin Urtasun, Aritz | |
| dc.contributor.author | Ugarte Martínez, María Dolores | |
| dc.contributor.department | Estadística, Informática y Matemáticas | es_ES |
| dc.contributor.department | Estatistika, Informatika eta Matematika | eu |
| dc.contributor.department | Institute for Advanced Materials and Mathematics - INAMAT2 | en |
| dc.date.accessioned | 2021-01-11T11:43:48Z | |
| dc.date.available | 2021-01-11T11:43:48Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Background: Ovarian cancer is a silent and largely asymptomatic cancer, leading to late diagnosis and worse prognosis. The late-stage detection and low survival rates, makes the study of the space-time evolution of ovarian cancer particularly relevant. In addition, research of this cancer in small areas (like provinces or counties) is still scarce. Methods: The study presented here covers all ovarian cancer deaths for women over 50 years of age in the provinces of Spain during the period 1989-2015. Spatio-temporal models have been fitted to smooth ovarian cancer mortality rates in age groups [50,60), [60,70), [70,80), and [80,+), borrowing information from spatial and temporal neighbours. Model fitting and inference has been carried out using the Integrated Nested Laplace Approximation (INLA) technique. Results: Large differences in ovarian cancer mortality among the age groups have been found, with higher mortality rates in the older age groups. Striking differences are observed between northern and southern Spain. The global temporal trends (by age group) reveal that the evolution of ovarian cancer over the whole of Spain has remained nearly constant since the early 2000s. Conclusion: Differences in ovarian cancer mortality exist among the Spanish provinces, years, and age groups. As the exact causes of ovarian cancer remain unknown, spatio-temporal analyses by age groups are essential to discover inequalities in ovarian cancer mortality. Women over 60 years of age should be the focus of follow-up studies as the mortality rates remain constant since 2002. High-mortality provinces should also be monitored to look for specific risk factors. | en |
| dc.description.sponsorship | This research has been supported by the Spanish Ministry of Science and Innovation (project MTM 2017-82553-R (AEI/FEDER, UE). | en |
| dc.format.extent | 13 p. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.1186/s12889-020-09267-3 | |
| dc.identifier.issn | 1471-2458 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/38971 | |
| dc.language.iso | eng | en |
| dc.publisher | BioMed Central | en |
| dc.relation.ispartof | BMC Public Health, 2020, 20:1244 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MTM2017-82553-R/ES/ | |
| dc.relation.publisherversion | https://doi.org/10.1186/s12889-020-09267-3 | |
| dc.rights | © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Age-space-time models | en |
| dc.subject | Disease mapping | en |
| dc.subject | INLA | en |
| dc.subject | Ovarian cancer mortality | en |
| dc.subject | Smoothing | en |
| dc.title | Space-time analysis of ovarian cancer mortality rates by age groups in Spanish provinces (1989-2015) | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
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