Premorbid adjustment and clinical correlates of cognitive impairment in first-episode psychosis: the PEPsCog study

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dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorCabrera, Bibiana
dc.contributor.authorBioque, Miquel
dc.contributor.authorMerchán-Naranjo, Jessica
dc.contributor.authorCorripio, Iluminada
dc.contributor.authorGonzález Pinto, Ana
dc.contributor.authorLobo, Antonio
dc.contributor.authorBombín, Igor
dc.contributor.authorSerna, Elena de la
dc.contributor.authorSanjuán, Julio
dc.contributor.authorParellada, Mara
dc.contributor.authorSáiz-Ruiz, Jerónimo
dc.contributor.authorBernardo, Miguel
dc.contributor.authorPEPs Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-01-29T19:25:04Z
dc.date.available2024-01-29T19:25:04Z
dc.date.issued2015
dc.date.updated2024-01-29T18:35:56Z
dc.description.abstractBackground: The extent to which socio-demographic, clinical, and premorbid adjustment variables contribute to cognitive deficits in first-episode schizophrenia spectrum disorders remains to be ascertained. Aims: To examine the pattern and magnitude of cognitive impairment in first-episode psychosis patients, the profile of impairment across psychosis subtypes and the associations with premorbid adjustment. Methods: 226 first-episode psychosis patients and 225 healthy controls were assessed in the PEPsCog study, as part of the PEPs study. Results: Patients showed slight to moderate cognitive impairment, verbal memory being the domain most impaired compared to controls. Broad affective spectrum patients had better premorbid IQ and outperformed the schizophrenia and other psychosis groups in executive function, and had better global cognitive function than the schizophrenia group. Adolescent premorbid adjustment together with age, gender, parental socio-economic status, and mean daily antipsychotic doses were the factors that best explained patients' cognitive performance. General and adolescent premorbid adjustment, age and parental socio-economic status were the best predictors of cognitive performance in controls. Conclusions: Poorer premorbid adjustment together with socio-demographic factors and higher daily antipsychotic doses were related to a generalized cognitive impairment and to a lower premorbid intellectual reserve, suggesting that neurodevelopmental impairment was present before illness onset.en
dc.description.sponsorshipHealth Department of the Government of Navarra (11/101 and 87/2014); Centro de Investigación Biomédica en Red de salud Mental, CIBERSAM, the Government of Catalonia, Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement (2014SGR441); University of the Basque Country UPV/EHU, CIBERSAM G16 and GIU12/7; Biocruces Health Research Institute, the Basque Goverment GV2011111080; GV201111140.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationCuesta, M. J., Sánchez-Torres, A. M., Cabrera, B., Bioque, M., Merchán-Naranjo, J., Corripio, I., González-Pinto, A., Lobo, A., Bombín, I., de la Serna, E., Sanjuan, J., Parellada, M., Saiz-Ruiz, J., Bernardo, M., PEPs Group (2015) Premorbid adjustment and clinical correlates of cognitive impairment in first-episode psychosis. The PEPsCog Study. Schizophrenia Research, 164(1-3), 65-73. https://doi.org/10.1016/j.schres.2015.02.022.en
dc.identifier.doi10.1016/j.schres.2015.02.022
dc.identifier.issn0920-9964
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/47238
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofSchizophrenia Research 164(1–3), 2015, 65-73en
dc.relation.publisherversionhttps://doi.org/10.1016/j.schres.2015.02.022
dc.rights© 2015 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSchizophrenia spectrum disordersen
dc.subjectFirst episode psychosisen
dc.subjectPremorbid adjustmenten
dc.subjectCognitionen
dc.titlePremorbid adjustment and clinical correlates of cognitive impairment in first-episode psychosis: the PEPsCog studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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