Olfactory characterization and training in older adults: protocol study

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dc.contributor.authorZambom Ferraresi, Fabíola
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorFernández Irigoyen, Joaquín
dc.contributor.authorLachén Montes, Mercedes
dc.contributor.authorCartas Cejudo, Paz
dc.contributor.authorLasarte, Juan José
dc.contributor.authorCasares, Noelia
dc.contributor.authorFernández, Secundino
dc.contributor.authorCedeño Veloz, Bernardo Abel
dc.contributor.authorMaraví-Aznar, Enrique
dc.contributor.authorUzcanga-Lacabe, María Itziar
dc.contributor.authorGalbete Jiménez, Arkaitz
dc.contributor.authorSantamaría Martínez, Enrique
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.departmentEstadística, Informática y Matemáticases_ES
dc.contributor.departmentEstatistika, Informatika eta Matematikaeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2022-04-12T06:27:07Z
dc.date.available2022-04-12T06:27:07Z
dc.date.issued2021
dc.description.abstractThe aim of this article is to present the research protocol for a prospective cohort study that will assess the olfactory function and the effect of an intervention based on olfactory training in healthy very old adults (≥75 years old). A convenience sample of 180 older people (50% female) will be recruited in three different environments: hospitalized control group (CH) with stable acute illness (n = 60); ambulatory control group (CA) of community-based living (n = 60); and an experimental odor training group (EOT) from nursing homes (n = 60). The odor training (OT) intervention will last 12 weeks. All the volunteers will be assessed at baseline; CA and EOT groups will also be assessed after 12 weeks. The primary end point will be change in olfactory capacity from baseline to 12 weeks period of intervention or control. The intervention effects will be assessed with the overall score achieved in Sniffin Sticks Test (SST) – Threshold, Discrimination, and Identification (TDI) extended version. Secondary end points will be changes in cognitive tasks, quality of life, mood, immune status, and functional capacity. All these measurements will be complemented with an immune fitness characterization and a deep proteome profiling of the olfactory epithelium (OE) cultured ex vivo. The current study will provide additional evidence to support the implementation of olfactory precision medicine and the development of immunomodulatory nasal therapies based on non-invasive procedures. The proposed intervention will also intend to increase the knowledge about the olfactory function in very elderly people, improve function and quality of life, and promote the recovery of the health.en
dc.description.sponsorshipThis work was funded by grants from the Spanish Ministry of Science Innovation and Universities (Ref. PID2019-110356RB-I00/AEI/10.13039/501100011033) to JF-I and ES, and Department of Economic and Business Development from Government of Navarra (INNOLFACT project; Ref. 0011-1411-2020-000028). NM-V received funding from 'la Caixa' Foundation (ID 100010434), under agreement LCF/PR/PR15/51100006.en
dc.format.extent10 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.3389/fnagi.2021.757081
dc.identifier.issn1663-4365
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/42715
dc.language.isoengen
dc.publisherFrontiers Mediaen
dc.relation.ispartofFrontiers in Aging Neuroscience, 13, December 2021en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110356RB-I00/ES/
dc.relation.publisherversionhttps://doi.org/10.3389/fnagi.2021.757081
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGeriatricen
dc.subjectImmune fitnessen
dc.subjectNeurodegenerative diseaseen
dc.subjectOdor trainingen
dc.subjectOlfactory dysfunctionen
dc.subjectOlfactory epitheliumen
dc.subjectProteome profileen
dc.subjectSmell senseen
dc.titleOlfactory characterization and training in older adults: protocol studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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