Label-free wavelength and phase detection based SMS fiber immunosensors optimized with cladding etching

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dc.contributor.authorCardona-Maya, Yamile
dc.contributor.authorSocorro Leránoz, Abián Bentor
dc.contributor.authorDel Villar, Ignacio
dc.contributor.authorCruz, José Luis
dc.contributor.authorCorres Sanz, Jesús María
dc.contributor.authorBotero-Cadavid, Juan F.
dc.contributor.departmentIngeniería Eléctrica y Electrónicaes_ES
dc.contributor.departmentIngeniaritza Elektrikoa eta Elektronikoaeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua 2016/PI044es
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua 2016/PC025es
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua 2016/PC026es
dc.date.accessioned2018-03-27T10:43:58Z
dc.date.available2020-03-07T00:00:10Z
dc.date.issued2018
dc.description.abstractThe performance of E-SMS (Etched Singlemode-Multimode-Singlemode) optical fiber structures as immunosensors has been assessed by the implementation of antibody/antigen immunoassays. Through this procedure it has been proven that E-SMS structures are effective and suitable optical platforms for label-free biosensing. Using the phase shift and tracking the wavelength response it was found that the fabricated E-SMS devices exhibited limits of detection (LOD) down up to concentrations of 0.2mg/L of antigens in solution. This was achieved by coating the E-SMS with an antibody-based biolayer (goat IgG) that is able to determine the presence of anti-goat IgG antigen. Both a wavelength detection and a fast Fourier transform (FFT) analysis technique were used to perform this analysis. The FFT method showed similar results to those observed with the most traditional wavelength analysis, but with the advantage of a simpler detection system that makes unnecessary the use of sophisticated optical interrogators.en
dc.description.sponsorshipThis work was supported in part by the Spanish Ministry of Education and Science - FEDER TEC 2016- 78047 and by the Government of Navarre through its projects with references: 2016/PI044, 2016/PC025 and 2016/PC026. This work was supported in part by the Colombian Administrative Department of Science, Technology and Innovation - Colciencias, through the Program for national doctorates, calling 617 of 2013, and by the project “BIOSENSORES A FIBRA ÓPTICA PARA LA DETECCIÓN RÁPIDA DE ENFERMEDADES” supported by the Universidad Nacional de Colombia (Hermes code 40834).en
dc.embargo.lift2020-03-07
dc.embargo.terms2020-03-07
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1016/j.snb.2018.03.002
dc.identifier.issn0925-4005
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/28092
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofSensors and Actuators B: Chemical, Vol. 265 (2018) pgs. 10–19en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/TEC2016-78047/
dc.relation.publisherversionhttps://doi.org/10.1016/j.snb.2018.03.002
dc.rights© 2018 Elsevier B.V. The manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFiber-optic biosensorsen
dc.subjectLabel-free immunosensorsen
dc.subjectEtched-SMSen
dc.subjectBio-layeren
dc.subjectIgG/Anti-IgG bindingen
dc.titleLabel-free wavelength and phase detection based SMS fiber immunosensors optimized with cladding etchingen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication88f69525-b7db-404e-97ad-b18e8cf0afc9
relation.isAuthorOfPublication4af62af3-50fe-47ee-a17c-bd4ffb52ebe3
relation.isAuthorOfPublication6d5c994f-9fde-4b1b-afef-b3edc10aefa0
relation.isAuthorOfPublication.latestForDiscovery88f69525-b7db-404e-97ad-b18e8cf0afc9

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