Publication: Polymicrobial infections: do bacteria behave differently depending on their neighbours?
| dc.contributor.author | Lasa Uzcudun, Íñigo | |
| dc.contributor.author | Solano Goñi, Cristina | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.date.accessioned | 2019-08-26T11:13:31Z | |
| dc.date.available | 2019-08-26T11:13:31Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Despite the number of examples that correlate interspecies interactions in polymicrobial infections with variations in pathogenicity and antibiotic susceptibility of individual organisms, antibiotic therapies are selected to target the most relevant pathogen, with no consideration of the consequences that the presence of other bacterial species may have in the pathogenicity and response to antimicrobial agents. In this issue of Virulence, Garcia-Perez et al. [ 10 ] applied replica plating of used wound dressings to assess the topography of distinct S. aureus types in chronic wounds of patients with the genetic blistering disease epidermolysis bullosa, which is characterized by the development of chronic wounds upon simple mechanical trauma. This approach led to the identification of two strains of S. aureus coexisting with Bacillus thuringiensis and Klebsiella oxytoca. S. aureus is highly prevalent in chronic wound infections, whereas B. thuringiensis and K. oxytoca are regarded as opportunistic pathogens. These bacterial species did not inhibit each other's growth under laboratory conditions, suggesting that they do not compete through the production of inhibitory compounds. Using a top-down proteomic approach to explore the inherent relationships between these co-existing bacteria, the exoproteomes of the staphylococcal isolates in monoculture and co-culture with B. thuringiensis or K. oxytoca were characterized by Mass Spectrometry. | en |
| dc.description.sponsorship | Ministerio de Economía y Competitividad (BIO2014-53530-R). | en |
| dc.format.extent | 3 p. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.1080/21505594.2018.1426520 | |
| dc.identifier.issn | 2150-5608 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/34677 | |
| dc.language.iso | eng | en |
| dc.publisher | Taylor & Francis | en |
| dc.relation.ispartof | Virulence, 9 (1), 895-897 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BIO2014-53530-R/ES/ | en |
| dc.relation.publisherversion | https://doi.org/10.1080/21505594.2018.1426520 | |
| dc.rights | © 2018 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
| dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Competition | en |
| dc.subject | Exoproteome | en |
| dc.subject | Microbial community | en |
| dc.subject | Polymicrobial infections | en |
| dc.subject | Staphylococcus aureus | en |
| dc.title | Polymicrobial infections: do bacteria behave differently depending on their neighbours? | en |
| dc.type | info:eu-repo/semantics/other | en |
| dc.type | Otros / Bestelakoak | es |
| dc.type.version | info:eu-repo/semantics/publishedVersion | en |
| dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
| dspace.entity.type | Publication | |
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