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Small area variations in non-affective first-episode psychosis: the role of socioeconomic and environmental factors

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dc.contributor.authorGutiérrez, Gerardoes_ES
dc.contributor.authorGoicoa Mangado, Tomás
dc.contributor.authorUgarte Martínez, María Dolores
dc.contributor.authorAranguren Conde, Lidiaes_ES
dc.contributor.authorCorrales, Asieres_ES
dc.contributor.authorGil Berrozpe, Gustavo Josées_ES
dc.contributor.authorLibrero, Juliánes_ES
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorPeralta Martín, Víctores_ES
dc.contributor.authorGarcía de Jalón, Elenaes_ES
dc.contributor.authorCuesta, Manuel J.es_ES
dc.contributor.authorMartínez, Matildees_ES
dc.contributor.authorOtero, Maríaes_ES
dc.contributor.authorAzcárate, Leirees_ES
dc.contributor.authorPereda, Nahiaes_ES
dc.contributor.authorMonclús, Fernandoes_ES
dc.contributor.authorMoreno, Lauraes_ES
dc.contributor.authorFernández, Albaes_ES
dc.contributor.authorAriz, Mari Cruzes_ES
dc.contributor.authorSabaté, Albaes_ES
dc.contributor.authorAquerreta, Ainhoaes_ES
dc.contributor.authorAguirre, Izaskunes_ES
dc.contributor.authorLizarbe, Tadeaes_ES
dc.contributor.authorBegué, María Josées_ES
dc.contributor.departmentEstadística, Informática y Matemáticases_ES
dc.contributor.departmentEstatistika, Informatika eta Matematikaeu
dc.contributor.departmentInstitute for Advanced Materials and Mathematics - INAMAT2en
dc.date.accessioned2023-10-27T07:54:16Z
dc.date.issued2023
dc.date.updated2023-10-27T06:51:33Z
dc.description.abstractBackground: There is strong evidence supporting the association between environmental factors and increased risk of non-affective psychotic disorders. However, the use of sound statistical methods to account for spatial variations associated with environmental risk factors, such as urbanicity, migration, or deprivation, is scarce in the literature. Methods: We studied the geographical distribution of non-affective first-episode psychosis (NA-FEP) in a northern region of Spain (Navarra) during a 54-month period considering area-level socioeconomic indicators as putative explanatory variables. We used several Bayesian hierarchical Poisson models to smooth the standardized incidence ratios (SIR). We included neighborhood-level variables in the spatial models as covariates. Results: We identified 430 NA-FEP cases over a 54-month period for a population at risk of 365,213 inhabitants per year. NA-FEP incidence risks showed spatial patterning and a significant ecological association with the migrant population, unemployment, and consumption of anxiolytics and antidepressants. The high-risk areas corresponded mostly to peripheral urban regions; very few basic health sectors of rural areas emerged as high-risk areas in the spatial models with covariates. Discussion: Increased rates of unemployment, the migrant population, and consumption of anxiolytics and antidepressants showed significant associations linked to the spatial-geographic incidence of NA-FEP. These results may allow targeting geographical areas to provide preventive interventions that potentially address modifiable environmental risk factors for NA-FEP. Further investigation is needed to understand the mechanisms underlying the associations between environmental risk factors and the incidence of NA-FEP.en
dc.description.sponsorshipThis study was funded by a grant from the Carlos III Health Institute of the Ministry of Science and Innovation of the Government of Spain (PI19/01698). It was also funded by project PID2020-113125RB-I00/MCIN/AEI/10.13039/501100011033.en
dc.embargo.lift2024-07-31
dc.embargo.terms2024-07-31
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGutiérrez, G., Goicoa, T., Ugarte, M. D., Aranguren, L., Corrales, A., Gil-Berrozpe, G., Librero, J., Sánchez-Torres, A. M., Peralta, V., García De Jalon, E., Cuesta, M. J., PEPsNa group, Martínez, M., Otero, M., Azcarate, L., Pereda, N., Monclús, F., Moreno, L., Fernández, A., … Begué, M. J. (2023). Small area variations in non-affective first-episode psychosis: The role of socioeconomic and environmental factors. European Archives of Psychiatry and Clinical Neuroscience. https://doi.org/10.1007/s00406-023-01665-zen
dc.identifier.doi10.1007/s00406-023-01665-z
dc.identifier.issn0940-1334
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/46655
dc.language.isoengen
dc.publisherSpringeren
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscience (2023)en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI19%2F01698/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113125RB-I00/ES/en
dc.relation.publisherversionhttps://doi.org/10.1007/s00406-023-01665-z
dc.rights© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023en
dc.rights.accessRightsAcceso embargado / Sarbidea bahitua dagoes
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccessen
dc.subjectEnvironmental risk factorsen
dc.subjectEpidemiologyen
dc.subjectFirst-episode psychosisen
dc.subjectIncidenceen
dc.titleSmall area variations in non-affective first-episode psychosis: the role of socioeconomic and environmental factorsen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.type.versionVersión aceptada / Onetsi den bertsioaes
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublication77ba75f3-a30d-4f01-8cc5-9de6d3a10d8d
relation.isAuthorOfPublicatione87ff19e-9d36-4286-989b-cafd391dff9d
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication.latestForDiscovery77ba75f3-a30d-4f01-8cc5-9de6d3a10d8d

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