An effort to make sense of antisense transcription in bacteria

Lasa Uzcudun, Íñigo; Toledo Arana, Alejandro; Gingeras, Thomas R.

Publication:
An effort to make sense of antisense transcription in bacteria

dc.contributor.author	Lasa Uzcudun, Íñigo
dc.contributor.author	Toledo Arana, Alejandro
dc.contributor.author	Gingeras, Thomas R.
dc.contributor.department	IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua	es_ES
dc.date.accessioned	2016-11-04T16:49:03Z
dc.date.available	2016-11-04T16:49:03Z
dc.date.issued	2012
dc.description	This is an accepted manuscript of an article published by Taylor & Francis in RNA Biology on August 1st 2012, available online: http://dx.doi.org/10.4161/rna.21167.	en
dc.description.abstract	Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed.	en
dc.description.sponsorship	A.T.-A. is recipient of “Ramon y Cajal” contracts from the Spanish Ministry of Science and Innovation. This research was supported by grants ERA-NET Pathogenomics (PIM2010EPA-00606), BIO2008-05284-C02, BIO2011-30503-C02 and BFU2011-23222 from Spanish Ministry of Economy and Competitiveness.	en
dc.format.mimetype	application/pdf	en
dc.identifier.doi	10.4161/rna.21167
dc.identifier.issn	1547-6286 (Print)
dc.identifier.issn	1555-8584 (Electronic)
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/22581
dc.language.iso	eng	en
dc.publisher	Taylor & Francis	en
dc.relation.ispartof	RNA Biology, Volume 9, 2012, Issue 8	en
dc.relation.projectID	info:eu-repo/grantAgreement/MICINN//BIO2008-05284-C02-01/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/MICINN//BIO2011-30503-C02-02/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/ES/6PN/BFU2011-23222	en
dc.relation.publisherversion	https://dx.doi.org/10.4161/rna.21167
dc.rights	© 2012 Landes Bioscience	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.subject	Overlapping transcription	en
dc.subject	RNase III	en
dc.subject	RNA processing	en
dc.subject	Bacteria	en
dc.subject	Transcriptome	en
dc.title	An effort to make sense of antisense transcription in bacteria	en
dc.type	info:eu-repo/semantics/article
dc.type.version	Versión aceptada / Onetsi den bertsioa	es
dc.type.version	info:eu-repo/semantics/acceptedVersion	en
dspace.entity.type	Publication
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