Altered cortical palmitoylation induces widespread molecular disturbances in Parkinson's disease

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dc.contributor.authorCervilla-Martínez Juan F.
dc.contributor.authorRodríguez-Gotor Juan J.
dc.contributor.authorWypijewski, Krzysztof J.
dc.contributor.authorFontán-Lozano Ángela
dc.contributor.authorWang, Tao
dc.contributor.authorSantamaría Martínez, Enrique
dc.contributor.authorFuller, William
dc.contributor.authorMejías, Rebeca
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2023-04-03T07:42:59Z
dc.date.available2023-04-03T07:42:59Z
dc.date.issued2022
dc.date.updated2023-04-03T07:32:38Z
dc.description.abstractThe relationship between Parkinson’s disease (PD), the second-most common neurodegenerative disease after Alzheimer’s disease, and palmitoylation, a post-translational lipid modification, is not well understood. In this study, to better understand the role of protein palmitoylation in PD and the pathways altered in this disease, we analyzed the differential palmitoyl proteome (palmitome) in the cerebral cortex of PD patients compared to controls (n = 4 per group). Data-mining of the cortical palmitome from PD patients and controls allowed us to: (i) detect a set of 150 proteins with altered palmitoylation in PD subjects in comparison with controls; (ii) describe the biological pathways and targets predicted to be altered by these palmitoylation changes; and (iii) depict the overlap between the differential palmitome identified in our study with protein interactomes of the PD-linked proteins α-synuclein, LRRK2, DJ-1, PINK1, GBA and UCHL1. In summary, we partially characterized the altered palmitome in the cortex of PD patients, which is predicted to impact cytoskeleton, mitochondrial and fibrinogen functions, as well as cell survival. Our study suggests that protein palmitoylation could have a role in the pathophysiology of PD, and that comprehensive palmitoyl-proteomics offers a powerful approach for elucidating novel cellular pathways modulated in this neurodegenerative disease.en
dc.description.sponsorshipThis work was partially funded by NIH (R21NS085358). JJRG had an Erasmus+ fellowship from an EU programme for education, training, youth, and sport. The Brain and Body Donation Program is supported by the National Institute on Aging (P30 AG19610 Arizona Alzheimer’s Disease Core Center), the Arizona Department of Health Services (contract 211002, Arizona Alzheimer’s Research Center), the Arizona Biomedical Research Commission (contracts 4001, 0011, 05-901 and 1001 to the Arizona Parkinson’s Disease Consortium)en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.citationCervilla-Martínez, J. F., Rodríguez-Gotor, J. J., Wypijewski, K. J., Fontán-Lozano, Á., Wang, T., Santamaría, E., Fuller, W., & Mejías, R. (2022). Altered Cortical Palmitoylation Induces Widespread Molecular Disturbances in Parkinson’s Disease. International Journal of Molecular Sciences, 23(22), 14018. https://doi.org/10.3390/ijms232214018en
dc.identifier.doi10.3390/ijms232214018
dc.identifier.issn1661-6596
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45016
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofInternational Journal of Molecular Sciences, 2022, 23(22), 1-18en
dc.relation.publisherversionhttps://doi.org/10.3390/ijms232214018
dc.rights© 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCerebral cortexen
dc.subjectInteractomeen
dc.subjectPalmitoylationen
dc.subjectParkinson´s diseaseen
dc.subjectProteomicsen
dc.titleAltered cortical palmitoylation induces widespread molecular disturbances in Parkinson's diseaseen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationabacfd17-2b93-4d99-bae2-52053d57401e
relation.isAuthorOfPublication.latestForDiscoveryabacfd17-2b93-4d99-bae2-52053d57401e

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