Multiparametric renal magnetic resonance imaging: a reproducibility study in renal allografts with stable function

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dc.contributor.authorEcheverría Chasco, Rebeca
dc.contributor.authorMartín Moreno, Paloma L.
dc.contributor.authorVidorreta, Marta
dc.contributor.authorAramendía Vidaurreta, Verónica
dc.contributor.authorCano, David
dc.contributor.authorVillanueva Larre, Arantxa
dc.contributor.authorBastarrika, Gorka
dc.contributor.authorFernández Seara, María A.
dc.contributor.authorGarcía Fernández, Nuria
dc.contributor.departmentIngeniería Eléctrica, Electrónica y de Comunicaciónes_ES
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.departmentIngeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzareneu
dc.date.accessioned2023-03-30T08:09:57Z
dc.date.available2023-03-30T08:09:57Z
dc.date.issued2023
dc.date.updated2023-03-30T07:58:01Z
dc.description.abstractMonitoring renal allograft function after transplantation is key for the early detection of allograft impairment, which in turn can contribute to preventing the loss of the allograft. Multiparametric renal MRI (mpMRI) is a promising noninvasive technique to assess and characterize renal physiopathology; however, few studies have employed mpMRI in renal allografts with stable function (maintained function over a long time period). The purposes of the current study were to evaluate the reproducibility of mpMRI in transplant patients and to characterize normal values of the measured parameters, and to estimate the labeling efficiency of Pseudo-Continuous Arterial Spin Labeling (PCASL) in the infrarenal aorta using numerical simulations considering experimental measurements of aortic blood flow profiles. The subjects were 20 transplant patients with stable kidney function, maintained over 1 year. The MRI protocol consisted of PCASL, intravoxel incoherent motion, and T1 inversion recovery. Phase contrast was used to measure aortic blood flow. Renal blood flow (RBF), diffusion coefficient (D), pseudo-diffusion coefficient (D*), flowing fraction (f), and T1 maps were calculated and mean values were measured in the cortex and medulla. The labeling efficiency of PCASL was estimated from simulation of Bloch equations. Reproducibility was assessed with the within-subject coefficient of variation, intraclass correlation coefficient, and Bland-Altman analysis. Correlations were evaluated using the Pearson correlation coefficient. The significance level was p less than 0.05. Cortical reproducibility was very good for T1, D, and RBF, moderate for f, and low for D*, while medullary reproducibility was good for T1 and D. Significant correlations in the cortex between RBF and f (r = 0.66), RBF and eGFR (r = 0.64), and D* and eGFR (r = 0.57) were found. Normal values of the measured parameters employing the mpMRI protocol in kidney transplant patients with stable function were characterized and the results showed good reproducibility of the techniques.en
dc.description.sponsorshipGovernment of Navarra; Grant Number: PC181-182 RM-RENAL Rebeca Echeverria-Chasco received Ph.D. grant support from Siemens Healthcare Spain.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationEcheverria‐Chasco, R., Martin‐Moreno, P. L., Garcia‐Fernandez, N., Vidorreta, M., Aramendia‐Vidaurreta, V., Cano, D., Villanueva, A., Bastarrika, G., & Fernández‐Seara, M. A. (2023). Multiparametric renal magnetic resonance imaging: A reproducibility study in renal allografts with stable function. NMR in Biomedicine, 36(2). https://doi.org/10.1002/nbm.4832en
dc.identifier.doi10.1002/nbm.4832
dc.identifier.issn0952-3480
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/44979
dc.language.isoengen
dc.publisherWileyen
dc.relation.ispartofNMR in Biomedicine, 2023; 36(2), 1-16en
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//PC181-182 RM-RENAL/
dc.relation.publisherversionhttps://doi.org/10.1002/nbm.4832
dc.rights© 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectArterial spin labelingen
dc.subjectIntravoxel incoherent motionen
dc.subjectKidney transplanten
dc.subjectMultiparametric MRIen
dc.subjectReproducibilityen
dc.subjectT1 mappingen
dc.titleMultiparametric renal magnetic resonance imaging: a reproducibility study in renal allografts with stable functionen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication5cfc3bb5-70a4-49da-9dcb-ea6cd22e0780
relation.isAuthorOfPublicationd3bfd5bf-8426-455b-bcc4-897ddb0d4c2e
relation.isAuthorOfPublication33560acb-8656-4761-98c1-a70a777c7552
relation.isAuthorOfPublication.latestForDiscoveryd3bfd5bf-8426-455b-bcc4-897ddb0d4c2e

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