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Persistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women: a follow-up study

dc.contributor.authorSoto de León, Sara
dc.contributor.authorRío Ospina, Luisa del
dc.contributor.authorCamargo, Milena
dc.contributor.authorSánchez, Ricardo
dc.contributor.authorMoreno Pérez, Darwin Andrés
dc.contributor.authorPérez Prados, Antonio
dc.contributor.authorPatarroyo, Manuel Elkin
dc.contributor.authorPatarroyo, Manuel Alfonso
dc.contributor.departmentEstadística e Investigación Operativaes_ES
dc.contributor.departmentEstatistika eta Ikerketa Operatiboaeu
dc.date.accessioned2015-09-30T07:35:24Z
dc.date.available2015-09-30T07:35:24Z
dc.date.issued2014
dc.description.abstractBackground: The design of new healthcare schemes which involve using molecular HPV screening means that both persistence and clearance data regarding the most prevalent types of HR-HPV occurring in cities in Colombia must be ascertained. Methods: This study involved 219 HPV positive women in all of whom 6 types of HR-HPV had been molecularly identified and quantified; they were followed-up for 2 years. The Kaplan-Meier survival function was used for calculating the time taken for the clearance of each type of HPV. The role of a group of independent variables concerning the time taken until clearance was evaluated using a Cox proportional-hazards regression model or parametric (log-logistic) methods when necessary. Regarding viral load, the Wilcoxon rank-sum test was used for measuring the difference of medians for viral load for each type, according to the state of infection (cleared or persistent). The Kruskal-Wallis test was used for evaluating the change in the women's colposcopy findings at the start of follow-up and at the end of it (whether due to clearance or the end of the follow-up period). Results: It was found that HPV-18 and HPV-31 types had the lowest probability of becoming cleared (1.76 and 2.75 per 100 patients/month rate, respectively). Women from Colombian cities other than Bogota had a greater probability of being cleared if they had HPV-16 (HR 2.58: 1.51-4.4 95% CI) or HPV-58 (1.79 time ratio: 1.33-2.39 95% CI) infection. Regarding viral load, HPV-45-infected women having 1 x 10(6) to 9.99 x 10(9) viral copies had better clearance compared to those having greater viral loads (1.61 time ratio: 1.01-2.57 95% CI). Lower HPV-31 viral load values were associated with this type's persistence and changes in colposcopy findings for HPV-16 gave the worst prognosis in women having low absolute load values. Conclusions: HPV infection clearance in this study was related to factors such as infection type, viral load and the characteristics of the cities from which the women came. Low viral load values would indicate viral persistence and a worse prognosis regarding a change in colposcopy findings.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1186/1471-2334-14-395
dc.identifier.issn1471-2334
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/18324
dc.language.isoengen
dc.publisherBioMed Centralen
dc.relation.ispartofBMC Infectious Diseases 2014, 14:395en
dc.relation.publisherversionhttps://dx.doi.org/10.1186/1471-2334-14-395
dc.rights© 2014 Soto-De León et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectHR-HPVen
dc.subjectPersistenceen
dc.subjectClearance timeen
dc.subjectColombiaen
dc.subjectFollow-up studyen
dc.subjectViral loaden
dc.titlePersistence, clearance and reinfection regarding six high risk human papillomavirus types in Colombian women: a follow-up studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dspace.entity.typePublication
relation.isAuthorOfPublicationbae41c1b-529a-4ecf-a8db-60b3558d5da0
relation.isAuthorOfPublication.latestForDiscoverybae41c1b-529a-4ecf-a8db-60b3558d5da0

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