High sensitive and selective C-reactive protein detection by means of lossy mode resonance based optical fiber devices
| dc.contributor.author | Zubiate Orzanco, Pablo | |
| dc.contributor.author | Ruiz Zamarreño, Carlos | |
| dc.contributor.author | Sánchez Zábal, Pedro | |
| dc.contributor.author | Matías Maestro, Ignacio | |
| dc.contributor.author | Arregui San Martín, Francisco Javier | |
| dc.contributor.department | Institute of Smart Cities - ISC | en |
| dc.contributor.department | Ingeniería Eléctrica y Electrónica | es_ES |
| dc.contributor.department | Ingeniaritza Elektrikoa eta Elektronikoa | eu |
| dc.contributor.funder | Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa | es |
| dc.date.accessioned | 2024-01-15T07:49:25Z | |
| dc.date.available | 2024-01-15T07:49:25Z | |
| dc.date.issued | 2017 | |
| dc.date.updated | 2024-01-15T07:39:19Z | |
| dc.description.abstract | This work presents the development of high sensitive, selective, fast and reusable C-reactive protein (CRP) aptasensors. This novel approach takes advantage of the utilization of high sensitive refractometers based on Lossy Mode Resonances generated by thin indium tin oxide (ITO) films fabricated onto the planar region of D-shaped optical fibers. CRP selectivity is obtained by means of the adhesion of a CRP specific aptamer chain onto the ITO film using the Layer-by-Layer (LbL) nano-assembly fabrication process. The sensing mechanism relies on resonance wavelength shifts originated by refractive index variations of the aptamer chain in presence of the target molecule. Fabricated devices show high selectivity to CRP when compared with other target molecules, such as urea or creatinine, while maintaining a low detection limit (0.0625 mg/L) and fast response time (61 s). Additionally, these sensors show a repetitive response for several days and are reusable after a cleaning process in ultrapure water. | en |
| dc.description.sponsorship | This work was supported by a Pre-Doctoral Research Grant of the Public University of Navarra, Spanish Economy and Competitiveness Ministry-Feder TEC2013-43679-R and Fundación CAN2015-70221 Research Grants. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Zubiate, P., Zamarreño, C.R., Sánchez, P., Matias, I.R., Arregui, F.J. (2017) High sensitive and selective C-reactive protein detection by means of lossy mode resonance based optical fiber devices. Biosensors & Bioelectronics, 93, 176-181. https://doi.org/10.1016/j.bios.2016.09.020. | en |
| dc.identifier.doi | 10.1016/j.bios.2016.09.020 | |
| dc.identifier.issn | 0956-5663 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/47046 | |
| dc.language.iso | eng | en |
| dc.publisher | Elsevier | en |
| dc.relation.ispartof | Biosensors and Bioelectronics 93 (2017) 176-181 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TEC2013-43679-R/ES/ | |
| dc.relation.publisherversion | https://doi.org/10.1016/j.bios.2016.09.020 | |
| dc.rights | © 2017 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Biosensors | en |
| dc.subject | C-reactive protein | en |
| dc.subject | Optical fiber | en |
| dc.subject | Lossy mode resonance | en |
| dc.subject | D-shaped | en |
| dc.title | High sensitive and selective C-reactive protein detection by means of lossy mode resonance based optical fiber devices | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dspace.entity.type | Publication | |
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