Regenerable LMR-based fiber optic immunosensor with a SnO2 metallic oxide thin film for label-free detection
| dc.contributor.author | Santano Rivero, Desiree | |
| dc.contributor.author | Zubiate Orzanco, Pablo | |
| dc.contributor.author | Socorro Leránoz, Abián Bentor | |
| dc.contributor.author | Del Villar, Ignacio | |
| dc.contributor.department | Ingeniería Eléctrica, Electrónica y de Comunicación | es_ES |
| dc.contributor.department | Ingeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritza | eu |
| dc.contributor.department | Institute of Smart Cities - ISC | en |
| dc.contributor.funder | Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa | |
| dc.date.accessioned | 2025-02-26T09:05:06Z | |
| dc.date.issued | 2025-05-15 | |
| dc.date.updated | 2025-02-26T08:58:13Z | |
| dc.description.abstract | This paper introduces the fabrication and characterization of a regenerable LMR-based, label-free optical fiber immunosensor. This innovative biosensor proposal was developed by functionalizing a SnO2 metallic oxide thin film deposited on a D-shaped optical fiber using a silanization protocol. The system successfully detected IgG - anti-IgG complexes in real-time in a range of concentrations from 0.5 to 10 ¿g/ml and achieved a limit of detection (LoD) of 0.12 μg/ml of anti-IgG. The biosensor was extensively tested to assess its capacity for regeneration, confirming that it can be reused repeatedly, reducing the overall cost and waste typically associated with disposable sensors. This regenerability has significant implications for a range of applications, providing a more sustainable and flexible approach to biosensing technology. | en |
| dc.description.sponsorship | This research was funded partially by the Spanish Agencia Estatal de Investigacion (MCIU/AEI/10.13039/501100011033/FEDER) through the project with reference PID2023-149895OB-I00, and also by the Public University of Navarre pre-doctoral research grant. | |
| dc.embargo.lift | 2027-05-15 | |
| dc.embargo.terms | 2027-05-15 | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Santano, D., Zubiate, P., Socorro-Leránoz, A. B., Del Villar, I. (2025). Regenerable LMR-based fiber optic immunosensor with a SnO2 metallic oxide thin film for label-free detection. Talanta, 287, 1-8. https://doi.org/10.1016/j.talanta.2025.127658. | |
| dc.identifier.doi | 10.1016/j.talanta.2025.127658 | |
| dc.identifier.issn | 0039-9140 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/53577 | |
| dc.language.iso | eng | |
| dc.publisher | Pergamon Press | |
| dc.relation.ispartof | Talanta (2025), vol. 287, 127658 | |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-149895OB-I00/ES/ | |
| dc.relation.publisherversion | https://doi.org/10.1016/j.talanta.2025.127658 | |
| dc.rights | © 2025 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0. | |
| dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Immunosensor | en |
| dc.subject | Optical fiber | en |
| dc.subject | Regenerable | en |
| dc.subject | Lossy mode resonance | en |
| dc.subject | Silanization | en |
| dc.title | Regenerable LMR-based fiber optic immunosensor with a SnO2 metallic oxide thin film for label-free detection | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dspace.entity.type | Publication | |
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