Publication: The hemodynamics of aneurysms treated with flow-diverting stents considering both stent and aneurysm/artery geometries
| dc.contributor.author | Cillo Velasco, Paulo Roberto | |
| dc.contributor.author | Luciano, Rafaello D. | |
| dc.contributor.author | Kelly, Michael E. | |
| dc.contributor.author | Peeling, Lissa | |
| dc.contributor.author | Malvè, Mauro | |
| dc.contributor.department | Ingeniería | es_ES |
| dc.contributor.department | Ingeniaritza | eu |
| dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua, PC086-087-088 CONDE | es |
| dc.date.accessioned | 2021-01-20T09:41:10Z | |
| dc.date.available | 2021-01-20T09:41:10Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Flow diverting stents are deployed to reduce the blood flow into the aneurysm, which would thereby induce thrombosis in the aneurysm sac; the stents prevent its rupture. The present study aimed to examine and quantify the impacts of different flow stents on idealized configurations of the cerebral artery. In our study, we considered a spherical sidewall aneurysm located on curved and tortuous idealized artery vessels and three stents with different porosities (70, 80 and 90%) for deployment. Using computational fluid dynamics, the local hemodynamics in the presence and absence of the stents were simulated, respectively, under the assumption that the blood flow was unsteady and non-Newtonian. The hemodynamic parameters, such as the intra-aneurysmal flow, velocity field and wall shear stress and its related indices, were examined and compared among the 12 cases simulated. The results illustrated that with the stent deployment, the intra-aneurysmal flow and the wall shear stress and its related indices were considerably modified depending on both stent and aneurysm/artery geometries, and that the intra-aneurysmal relative residence time increased rapidly with decreasing stent porosity in all the vessel configurations. These results also inform the rationale for selecting stents for treating aneurysms of different configurations. | en |
| dc.description.sponsorship | This research was funded by the Saskatchewan Health Research Foundation (SHRF grant reference #2784). M. Malvè was supported by grant PRX17/00335 financed by the Spanish Ministry of Education within the National Program 'Salvador de Madariaga'. The support of the Spanish Ministry of Economy, Industry and Competitiveness through research project DPI2017-83259-R (AEI/FEDER, UE) and of the Department of Economic Development of the Navarra Government through research project PC086-087-088 CONDE is highly appreciated. Finally, we gratefully acknowledge the Instituto de Salud Carlos III (ISCIII) through the CIBER-BBN initiative. | en |
| dc.description.sponsorship | This research was funded by the Saskatchewan Health Research Foundation (SHRF grant reference #2784). M. Malvé was supported by grant PRX17/00335 financed by the Spanish Ministry of Education within the National Program "Salvador de Madariaga." The support of the Spanish Ministry of Economy, Industry and Competitiveness through research project DPI2017-83259-R (AEI/FEDER, UE) and of the Department of Economic Development of the Navarra Government through research project PC086-087-088 CONDE is highly appreciated. Finally, we gratefully acknowledge the Instituto de Salud Carlos III (ISCIII) through the CIBER-BBN initiative. | en |
| dc.format.extent | 20 p. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.3390/APP10155239 | |
| dc.identifier.issn | 2076-3417 (Electronic) | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/39019 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | en |
| dc.relation.ispartof | Applied Sciences 2020, 10(15), 5239 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/DPI2017-83259-R/ES/ | en |
| dc.relation.publisherversion | https://doi.org/10.3390/APP10155239 | |
| dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Cerebral aneurysm | en |
| dc.subject | CFD | en |
| dc.subject | Flow diverting stent | en |
| dc.subject | Time averaged wall shear stress | en |
| dc.subject | Oscillatory shear index | en |
| dc.subject | Relative residence time | en |
| dc.title | The hemodynamics of aneurysms treated with flow-diverting stents considering both stent and aneurysm/artery geometries | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | en |
| dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | aa62429b-fef0-4a2c-9d96-43dbf7f63675 | |
| relation.isAuthorOfPublication.latestForDiscovery | aa62429b-fef0-4a2c-9d96-43dbf7f63675 |