Fiber-based early diagnosis of venous thromboembolic disease by label-free D-dimer detection

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dc.contributor.authorZubiate Orzanco, Pablo
dc.contributor.authorUrrutia Azcona, Aitor
dc.contributor.authorRuiz Zamarreño, Carlos
dc.contributor.authorEgea Urra, Josune
dc.contributor.authorFernández Irigoyen, Joaquín
dc.contributor.authorGiannetti, Ambra
dc.contributor.authorBaldini, Francesco
dc.contributor.authorDíaz Lucas, Silvia
dc.contributor.authorMatías Maestro, Ignacio
dc.contributor.authorArregui San Martín, Francisco Javier
dc.contributor.authorSantamaría Martínez, Enrique
dc.contributor.authorChiavaioli, Francesco
dc.contributor.authorDel Villar, Ignacio
dc.contributor.departmentIngeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzareneu
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.departmentIngeniería Eléctrica, Electrónica y de Comunicaciónes_ES
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2020-03-06T10:04:34Z
dc.date.available2020-03-06T10:04:34Z
dc.date.issued2019
dc.description.abstractD-dimer is a useful diagnostic biomarker for deep vein thrombosis or pulmonary embolism, collectively referred to as venous thromboembolism (VTE). The ability to detect in real-time the amount of D-dimer with a fast and reliable method is a key step to anticipate the appearance of these diseases. Here, the results of a highly specific and sensitive biosensor for the detection of D-dimer based on lossy mode resonance in fiber optics are presented. The unique features of specialty fibers in light management integrated with microfluidics allow detecting D-dimer in human serum with a detection limit of 100 ng/mL, a value 5-fold below the clinical cutoff value. Comparison of the results achieved with mass-spectrometry-based proteomics, which allows for the identification of beta- and gamma-chains of fibrinogen, demonstrates the ability of our platform to specifically (>90%) recognize D-dimer. Therefore, this technology potentially represents a paradigm shift in the development of a simple, high-specificity and label-free biosensing platform, which can be applied to speed up diagnostic healthcare processes of venous thromboembolism toward an early diagnostic and personalized treatment system.en
dc.description.sponsorshipThis work is funded by grants from the Spanish Agencia Estatal de Investigación (AEI) and European Regional Development Fund (FEDER) (TEC2016-78047-R) and the Department of Economic Development from Government of Navarra (REF. PC023-24-25 , PC081-082 , and PI031). The Proteomics Unit of Navarrabiomed is a member of Proteored, PRB3-ISCIII, and is supported by grant PT17/0019/009, of the PE I+D+I 2013–2016 funded by ISCIII and FEDER. This work is partly funded by the European Commission, Directorate-General Communications Networks, Content and Technology (DG CONNECT) under the ERA-NET Cofund scheme - Horizon 2020 'Horizon 2020 – the Framework Programme for Research and Innovation ( 2014–2020 )' for the project OPTIMO and by National Research Council of Italy (CNR) within the Short Term Mobility program (STM 2017 ).en
dc.format.extent10 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1016/j.biosx.2019.100026
dc.identifier.issn2590-1370
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/36429
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofBiosensors and Bioelectronics: X 2 2019 100026en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/TEC2016-78047-R/
dc.relation.publisherversionhttps://doi.org/10.1016/j.biosx.2019.100026
dc.rights© 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectOptical biosensoren
dc.subjectLossy mode resonanceen
dc.subjectD-dimeren
dc.subjectVenous thromboembolismen
dc.subjectNanocoated fiberen
dc.titleFiber-based early diagnosis of venous thromboembolic disease by label-free D-dimer detectionen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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