Publication: Fiber-based early diagnosis of venous thromboembolic disease by label-free D-dimer detection
dc.contributor.author | Zubiate Orzanco, Pablo | |
dc.contributor.author | Urrutia Azcona, Aitor | |
dc.contributor.author | Ruiz Zamarreño, Carlos | |
dc.contributor.author | Egea Urra, Josune | |
dc.contributor.author | Fernández Irigoyen, Joaquín | |
dc.contributor.author | Giannetti, Ambra | |
dc.contributor.author | Baldini, Francesco | |
dc.contributor.author | Díaz Lucas, Silvia | |
dc.contributor.author | Matías Maestro, Ignacio | |
dc.contributor.author | Arregui San Martín, Francisco Javier | |
dc.contributor.author | Santamaría Martínez, Enrique | |
dc.contributor.author | Chiavaioli, Francesco | |
dc.contributor.author | Del Villar, Ignacio | |
dc.contributor.department | Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren | eu |
dc.contributor.department | Institute of Smart Cities - ISC | en |
dc.contributor.department | Ingeniería Eléctrica, Electrónica y de Comunicación | es_ES |
dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua | es |
dc.date.accessioned | 2020-03-06T10:04:34Z | |
dc.date.available | 2020-03-06T10:04:34Z | |
dc.date.issued | 2019 | |
dc.description.abstract | D-dimer is a useful diagnostic biomarker for deep vein thrombosis or pulmonary embolism, collectively referred to as venous thromboembolism (VTE). The ability to detect in real-time the amount of D-dimer with a fast and reliable method is a key step to anticipate the appearance of these diseases. Here, the results of a highly specific and sensitive biosensor for the detection of D-dimer based on lossy mode resonance in fiber optics are presented. The unique features of specialty fibers in light management integrated with microfluidics allow detecting D-dimer in human serum with a detection limit of 100 ng/mL, a value 5-fold below the clinical cutoff value. Comparison of the results achieved with mass-spectrometry-based proteomics, which allows for the identification of beta- and gamma-chains of fibrinogen, demonstrates the ability of our platform to specifically (>90%) recognize D-dimer. Therefore, this technology potentially represents a paradigm shift in the development of a simple, high-specificity and label-free biosensing platform, which can be applied to speed up diagnostic healthcare processes of venous thromboembolism toward an early diagnostic and personalized treatment system. | en |
dc.description.sponsorship | This work is funded by grants from the Spanish Agencia Estatal de Investigación (AEI) and European Regional Development Fund (FEDER) (TEC2016-78047-R) and the Department of Economic Development from Government of Navarra (REF. PC023-24-25 , PC081-082 , and PI031). The Proteomics Unit of Navarrabiomed is a member of Proteored, PRB3-ISCIII, and is supported by grant PT17/0019/009, of the PE I+D+I 2013–2016 funded by ISCIII and FEDER. This work is partly funded by the European Commission, Directorate-General Communications Networks, Content and Technology (DG CONNECT) under the ERA-NET Cofund scheme - Horizon 2020 'Horizon 2020 – the Framework Programme for Research and Innovation ( 2014–2020 )' for the project OPTIMO and by National Research Council of Italy (CNR) within the Short Term Mobility program (STM 2017 ). | en |
dc.format.extent | 10 p. | |
dc.format.mimetype | application/pdf | en |
dc.identifier.doi | 10.1016/j.biosx.2019.100026 | |
dc.identifier.issn | 2590-1370 | |
dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/36429 | |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.relation.ispartof | Biosensors and Bioelectronics: X 2 2019 100026 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/TEC2016-78047-R | en |
dc.relation.publisherversion | https://doi.org/10.1016/j.biosx.2019.100026 | |
dc.rights | © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. | en |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Optical biosensor | en |
dc.subject | Lossy mode resonance | en |
dc.subject | D-dimer | en |
dc.subject | Venous thromboembolism | en |
dc.subject | Nanocoated fiber | en |
dc.title | Fiber-based early diagnosis of venous thromboembolic disease by label-free D-dimer detection | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | Artículo / Artikulua | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 5362455c-45c7-4da4-9627-218e3bc1b1f1 | |
relation.isAuthorOfPublication | 6b00af66-5db0-4efb-a851-c0da501da094 | |
relation.isAuthorOfPublication | f85c4fed-8804-4e02-b746-0855066291e3 | |
relation.isAuthorOfPublication | 86d1b76e-4790-40b1-a3ec-72331c5c6199 | |
relation.isAuthorOfPublication | 29e053da-64b8-48f9-8763-1a5038acf033 | |
relation.isAuthorOfPublication | bbb769e0-e56c-4b53-8e0b-cf33da20a35d | |
relation.isAuthorOfPublication | 90bd9817-d6cc-4907-ac5c-eb0d6317c3f7 | |
relation.isAuthorOfPublication | abacfd17-2b93-4d99-bae2-52053d57401e | |
relation.isAuthorOfPublication | 4af62af3-50fe-47ee-a17c-bd4ffb52ebe3 | |
relation.isAuthorOfPublication.latestForDiscovery | 5362455c-45c7-4da4-9627-218e3bc1b1f1 |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed to upon submission
- Description: