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Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents

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dc.contributor.authorGandía, Davides_ES
dc.contributor.authorGandarias, Lucíaes_ES
dc.contributor.authorRodrigo, Iraties_ES
dc.contributor.authorRobles García, Joshuaes_ES
dc.contributor.authorDas, Rajaes_ES
dc.contributor.authorGarayo Urabayen, Eneko
dc.contributor.authorGarcía, José Ángeles_ES
dc.contributor.departmentCienciases_ES
dc.contributor.departmentZientziakeu
dc.date.accessioned2020-02-18T13:10:07Z
dc.date.available2020-02-18T13:10:07Z
dc.date.issued2019
dc.description.abstractMagnetotactic bacteria are aquatic microorganisms that internally biomineralize chains of magnetic nanoparticles (called magnetosomes) and use them as a compass. Here it is shown that magnetotactic bacteria of the strain Magnetospirillum gryphiswaldense present high potential as magnetic hyperthermia agents for cancer treatment. Their heating efficiency or specific absorption rate is determined using both calorimetric and AC magnetometry methods at different magnetic field amplitudes and frequencies. In addition, the effect of the alignment of the bacteria in the direction of the field during the hyperthermia experiments is also investigated. The experimental results demonstrate that the biological structure of the magnetosome chain of magnetotactic bacteria is perfect to enhance the hyperthermia efficiency. Furthermore, fluorescence and electron microscopy images show that these bacteria can be internalized by human lung carcinoma cells A549, and cytotoxicity studies reveal that they do not affect the viability or growth of the cancer cells. A preliminary in vitro hyperthermia study, working on clinical conditions, reveals that cancer cell proliferation is strongly affected by the hyperthermia treatment, making these bacteria promising candidates for biomedical applications.en
dc.description.sponsorshipSpanish Government is acknowledged for funding under the project number MAT2017-83631-C3. USF coauthors acknowledge support from U.S. Department of Energy, Office of Basic Energy Sciences under Award No. DE-FG02-07ER46438.en
dc.format.extent12 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1002/smll.201902626
dc.identifier.issn1613-6810
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/36283
dc.language.isoengen
dc.publisherWileyen
dc.relation.ispartofSmall, 2019, 15, 1902626en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2017-83631-C3-2-R/ES/en
dc.relation.publisherversionhttps://doi.org/10.1002/smll.201902626
dc.rights© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The copyright line for this article was changed on 19 October 2019 after original online publication.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCancer therapyen
dc.subjectCytotoxicityen
dc.subjectInternalizationen
dc.subjectMagnetic hyperthermiaen
dc.subjectMagnetotactic bacteriaen
dc.titleUnlocking the potential of magnetotactic bacteria as magnetic hyperthermia agentsen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublicationef0a109c-acf3-4a8f-bdf8-c9b4fcbf1172
relation.isAuthorOfPublication.latestForDiscoveryef0a109c-acf3-4a8f-bdf8-c9b4fcbf1172

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