Antiviral potential and chemical composition of wild Baccharis crispa Spreng: populations (Asteraceae) from Córdoba, Argentina: perspective on population variability

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dc.contributor.authorLingua, Giuliana
dc.contributor.authorChaves, Ana Guadalupe
dc.contributor.authorAguilar, Juan Javier
dc.contributor.authorMartínez, Florencia
dc.contributor.authorGómez, Tomás Isaac
dc.contributor.authorRucci, Kevin Alen
dc.contributor.authorTorres, Lorena E.
dc.contributor.authorAncín Azpilicueta, Carmen
dc.contributor.authorEsparza Catalán, Irene
dc.contributor.authorJiménez Moreno, Nerea
dc.contributor.authorContigiani, Marta
dc.contributor.authorNúñez Montoya, Susana
dc.contributor.authorKonigheim, Brenda S.
dc.contributor.departmentCienciases_ES
dc.contributor.departmentZientziakeu
dc.contributor.departmentInstitute for Advanced Materials and Mathematics - INAMAT2en
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.date.accessioned2025-01-21T18:57:24Z
dc.date.available2025-01-21T18:57:24Z
dc.date.issued2024-11-01
dc.date.updated2025-01-21T18:45:50Z
dc.description.abstractMedicinal plants have been explored worldwide as potential alternatives for the prevention and treatment of different diseases, including viral infections. Baccharis crispa Spreng. (Asteraceae) is a native medicinal species widely used in South America. Given the influence of genetic and environmental factors on secondary metabolites biosynthesis and accumulation, this study aimed to evaluate the in vitro antiviral activity of four wild populations of B. crispa from Córdoba, Argentina, and assess the variability in their bioactivity and chemical composition. The cytotoxicity of chloroform, ethanol, and aqueous extracts from aerial parts was evaluated by the neutral red uptake method. Antiviral and virucidal activity against herpes simplex virus type 1 (HSV-1) and chikungunya virus (CHIKV) were assessed via plaque-forming unit (PFU) reduction assay. Phytochemical analyses of the extracts were conducted using HPLC-ESI- MS/MS. The Puesto Pedernera population showed the strongest antiviral activity, with inhibition rates of 82% for CHIKV and 79% against HSV-1, as well as potent virucidal effects, reducing PFU formation by up to 5 logarithms for both viruses. Remarkably, ethanol extract exhibited the least toxicity and strongest inhibitory activity. Villa del Parque population was inactive. We identified 38 secondary metabolites, predominantly phenolic acids (12) and flavonoids (18), in varying proportions. Delphinidin and delphinidin-3-glucoside are described for the first time in the species. Differences in phytochemical profiles were observed among extract types and populations. Key phenolic compounds showed moderate positive correlations with the evaluated bioactivities, emphasizing the complexity of phytochemical properties and interactions. These results highlight the therapeutic potential of B. crispa extracts against viral infections and underscore the importance of considering the geographical source of plant material in bioactivity evaluations.en
dc.description.sponsorshipThis research was funded by SECyT-UNC (Type FORMAR s/Resol. 2020-233-E-UNCSECYT# ACTIP and CONSOLIDAR Nº 411/18; 203/14). The acquisition of the HPLC-ESI-QTRAP equipment was possible thanks to the co-financing of the Ministry of Science, Innovation and Universities of the Spanish Government and the FEDER program of the European Union (Project: EQC2018-005202-P) and the Universidad Pública de Navarra.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLingua, G., Chaves, A. G., Aguilar, J. J., Martinez, F., Gomez, T. I., Rucci, K. A., Torres, L. E., Ancín-Azpilicueta, C., Esparza, I., Jiménez-Moreno, N., Contigiani, M., Nuñez Montoya, S., Konigheim, B. S. (2024) Antiviral potential and chemical composition of wild Baccharis crispa Spreng: populations (Asteraceae) from Córdoba, Argentina: perspective on population variability. Plants, 13(21), 1-18. https://doi.org/10.3390/plants13213077.
dc.identifier.doi10.3390/plants13213077
dc.identifier.issn2223-7747
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53031
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofPlants 2024, 13(21), 3077
dc.relation.publisherversionhttps://doi.org/10.3390/plants13213077
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNatural productsen
dc.subjectPopulation variabilityen
dc.subjectBioactivitiesen
dc.subjectHerpes simplex virusen
dc.subjectChikungunya virusen
dc.titleAntiviral potential and chemical composition of wild Baccharis crispa Spreng: populations (Asteraceae) from Córdoba, Argentina: perspective on population variabilityen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication0c68430e-1a8d-4e76-a5db-679f3359e8c4
relation.isAuthorOfPublicatione1ebcfa4-cbe3-44f5-93a8-75b06d0b5825
relation.isAuthorOfPublication18cd8a55-3a7a-4990-950b-e44f9cf81991
relation.isAuthorOfPublication.latestForDiscovery0c68430e-1a8d-4e76-a5db-679f3359e8c4

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