Publication: Mannose receptor may be involved in small ruminant lentivirus pathogenesis
dc.contributor.author | Crespo Otano, Helena | |
dc.contributor.author | Jauregui, Paula | |
dc.contributor.author | Glaría Ezquer, Idoia | |
dc.contributor.author | Sanjosé, Leticia | |
dc.contributor.author | Polledo, Laura | |
dc.contributor.author | García Marín, Juan F. | |
dc.contributor.author | Luján, Lluís | |
dc.contributor.author | Andrés Cara, Damián de | |
dc.contributor.author | Amorena Zabalza, Beatriz | |
dc.contributor.author | Reina Arias, Ramsés | |
dc.contributor.department | IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua | es_ES |
dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua: IIQ14064.RI1 | |
dc.contributor.funder | Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa | |
dc.date.accessioned | 2015-09-30T07:35:23Z | |
dc.date.available | 2015-09-30T07:35:23Z | |
dc.date.issued | 2012 | |
dc.description.abstract | Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n = 3), seronegative (n = 3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n = 1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis. | en |
dc.description.sponsorship | Funded by grants from CICYT AGL2010-22341-C04-01 and Gobierno de Navarra IIQ14064.RI1. We acknowledge the Public University of Navarra and CSIC for fellowships and the JAE-contract (HC and RR). | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.doi | 10.1186/1297-9716-43-43 | |
dc.identifier.issn | 0928-4249 (print) | |
dc.identifier.issn | 1297-9716 (electronic) | |
dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/18320 | |
dc.language.iso | eng | en |
dc.publisher | BioMed Central | en |
dc.relation.ispartof | Veterinary Research 2012, 43:43 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//AGL2010-22341-C04-01/ES/ | en |
dc.relation.publisherversion | https://dx.doi.org/10.1186/1297-9716-43-43 | |
dc.rights | © 2012 Crespo et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | |
dc.subject | Maedi Visna | en |
dc.subject | Alveolar macrophages | en |
dc.subject | Virus-infection | en |
dc.subject | Sheep | en |
dc.subject | Expression | en |
dc.subject | Diagnosis | en |
dc.subject | Correlate | en |
dc.subject | Lesion | en |
dc.subject | System | en |
dc.subject | Load | en |
dc.title | Mannose receptor may be involved in small ruminant lentivirus pathogenesis | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | Artículo / Artikulua | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dspace.entity.type | Publication | |
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