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Mannose receptor may be involved in small ruminant lentivirus pathogenesis

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dc.contributor.authorCrespo Otano, Helena
dc.contributor.authorJauregui, Paula
dc.contributor.authorGlaría Ezquer, Idoia
dc.contributor.authorSanjosé, Leticia
dc.contributor.authorPolledo, Laura
dc.contributor.authorGarcía Marín, Juan F.
dc.contributor.authorLuján, Lluís
dc.contributor.authorAndrés Cara, Damián de
dc.contributor.authorAmorena Zabalza, Beatriz
dc.contributor.authorReina Arias, Ramsés
dc.contributor.departmentIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes_ES
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua: IIQ14064.RI1
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.date.accessioned2015-09-30T07:35:23Z
dc.date.available2015-09-30T07:35:23Z
dc.date.issued2012
dc.description.abstractThirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n = 3), seronegative (n = 3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n = 1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis.en
dc.description.sponsorshipFunded by grants from CICYT AGL2010-22341-C04-01 and Gobierno de Navarra IIQ14064.RI1. We acknowledge the Public University of Navarra and CSIC for fellowships and the JAE-contract (HC and RR).en
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1186/1297-9716-43-43
dc.identifier.issn0928-4249 (print)
dc.identifier.issn1297-9716 (electronic)
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/18320
dc.language.isoengen
dc.publisherBioMed Centralen
dc.relation.ispartofVeterinary Research 2012, 43:43en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//AGL2010-22341-C04-01/ES/en
dc.relation.publisherversionhttps://dx.doi.org/10.1186/1297-9716-43-43
dc.rights© 2012 Crespo et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/
dc.subjectMaedi Visnaen
dc.subjectAlveolar macrophagesen
dc.subjectVirus-infectionen
dc.subjectSheepen
dc.subjectExpressionen
dc.subjectDiagnosisen
dc.subjectCorrelateen
dc.subjectLesionen
dc.subjectSystemen
dc.subjectLoaden
dc.titleMannose receptor may be involved in small ruminant lentivirus pathogenesisen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dspace.entity.typePublication
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relation.isAuthorOfPublicationb8d67008-109a-45c4-b632-218257bb3511
relation.isAuthorOfPublication50c83dcd-b739-4348-b0f0-3a230e16c398
relation.isAuthorOfPublication465b6837-c1f0-4390-85fd-9614dc59752d
relation.isAuthorOfPublication5eb332ef-80cd-4c2b-942f-e48c9d3725f2
relation.isAuthorOfPublication.latestForDiscoverye28c17f3-459d-4b77-9d08-2c325e7150da

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