Spatial gender-age-period-cohort analysis of pancreatic cancer mortality in Spain (1990-2013)

Etxeberria Andueza, Jaione; Goicoa Mangado, Tomás; López Abente, Gonzalo; Riebler, Andrea; Ugarte Martínez, María Dolores

Spatial gender-age-period-cohort analysis of pancreatic cancer mortality in Spain (1990-2013)

dc.contributor.author	Etxeberria Andueza, Jaione
dc.contributor.author	Goicoa Mangado, Tomás
dc.contributor.author	López Abente, Gonzalo
dc.contributor.author	Riebler, Andrea
dc.contributor.author	Ugarte Martínez, María Dolores
dc.contributor.department	Estatistika eta Ikerketa Operatiboa	eu
dc.contributor.department	Institute for Advanced Materials and Mathematics - INAMAT2	en
dc.contributor.department	Estadística e Investigación Operativa	es_ES
dc.contributor.funder	Gobierno de Navarra / Nafarroako Gobernua, 113, Res.2186/2014	es
dc.date.accessioned	2018-09-06T12:20:22Z
dc.date.available	2018-09-06T12:20:22Z
dc.date.issued	2017
dc.description.abstract	Recently, the interest in studying pancreatic cancer mortality has increased due to its high lethality. In this work a detailed analysis of pancreatic cancer mortality in Spanish provinces was performed using recent data. A set of multivariate spatial gender-age-period-cohort models was considered to look for potential candidates to analyze pancreatic cancer mortality rates. The selected model combines features of APC (age-period-cohort) models with disease mapping approaches. To ensure model identifiability sum-to-zero constraints were applied. A fully Bayesian approach based on integrated nested Laplace approximations (INLA) was considered for model fitting and inference. Sensitivity analyses were also conducted. In general, estimated average rates by age, cohort, and period are higher in males than in females. The higher differences according to age between males and females correspond to the age groups [65, 70), [70, 75), and [75, 80). Regarding the cohort, the greatest difference between men and women is observed for those born between the forties and the sixties. From there on, the younger the birth cohort is, the smaller the difference becomes. Some cohort differences are also identified by regions and age-groups. The spatial pattern indicates a North-South gradient of pancreatic cancer mortality in Spain, the provinces in the North being the ones with the highest effects on mortality during the studied period. Finally, the space-time evolution shows that the space pattern has changed little over time.	en
dc.description.sponsorship	This work was supported by Spanish Ministry of Economy and Competitiveness (Project MTM 2014-51992-R) (Ugarte, Etxeberria, Goicoa) and Health Department of the Navarre Government (Project 113, Res.2186/2014) (Ugarte, Etxeberria, Goicoa).	en
dc.format.mimetype	application/pdf	en
dc.format.mimetype	application/zip	en
dc.identifier.doi	10.1371/journal.pone.0169751
dc.identifier.issn	1932-6203
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/30553
dc.language.iso	eng	en
dc.publisher	Public Library of Science	en
dc.relation.ispartof	Plos One, 12(2):e0169751	en
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//MTM2014-51992-R/ES/
dc.relation.publisherversion	https://doi.org/10.1371/journal.pone.0169751
dc.rights	© 2017 Etxeberria et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Pancreatic cancer mortality	en
dc.subject	Spain	en
dc.title	Spatial gender-age-period-cohort analysis of pancreatic cancer mortality in Spain (1990-2013)	en
dc.type	info:eu-repo/semantics/article
dc.type.version	info:eu-repo/semantics/publishedVersion
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