Small ruminant macrophage polarization may play a pivotal role on lentiviral infection
| dc.contributor.author | Crespo Otano, Helena | |
| dc.contributor.author | Bertolotti, Luigi | |
| dc.contributor.author | Juganaru, Magda | |
| dc.contributor.author | Glaría Ezquer, Idoia | |
| dc.contributor.author | Andrés Cara, Damián de | |
| dc.contributor.author | Amorena Zabalza, Beatriz | |
| dc.contributor.author | Rosati, Sergio | |
| dc.contributor.author | Reina Arias, Ramsés | |
| dc.contributor.department | IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua | es_ES |
| dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua: IIQ14064.RI1 | es |
| dc.contributor.funder | Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa | es |
| dc.date.accessioned | 2015-09-30T07:35:22Z | |
| dc.date.available | 2015-09-30T07:35:22Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Small ruminant lentiviruses (SRLV) infect the monocyte/macrophage lineage inducing a long-lasting infection affecting body condition, production and welfare of sheep and goats all over the world. Macrophages play a pivotal role on the host's innate and adaptative immune responses against parasites by becoming differentially activated. Macrophage heterogeneity can tentatively be classified into classically differentiated macrophages (M1) through stimulation with IFN-gamma displaying an inflammatory profile, or can be alternatively differentiated by stimulation with IL-4/IL-13 into M2 macrophages with homeostatic functions. Since infection by SRLV can modulate macrophage functions we explored here whether ovine and caprine macrophages can be segregated into M1 and M2 populations and whether this differential polarization represents differential susceptibility to SRLV infection. We found that like in human and mouse systems, ovine and caprine macrophages can be differentiated with particular stimuli into M1/M2 subpopulations displaying specific markers. In addition, small ruminant macrophages are plastic since M1 differentiated macrophages can express M2 markers when the stimulus changes from IFN-gamma to IL-4. SRLV replication was restricted in M1 macrophages and increased in M2 differentiated macrophages respectively according to viral production. Identification of the infection pathways in macrophage populations may provide new targets for eliciting appropriate immune responses against SRLV infection. | en |
| dc.description.sponsorship | This work was funded by grants from CICYT (no. AGL2010-22341-C04-01), and the Government of Navarra (no. IIQ14064.RI1). We acknowledge the Public University of Navarra and CSIC for fellowships and the JAE-contract (HC and RR). | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.1186/1297-9716-44-83 | |
| dc.identifier.issn | 0928-4249 (print) | |
| dc.identifier.issn | 1297-9716 (electronic) | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/18319 | |
| dc.language.iso | eng | en |
| dc.publisher | BioMed Central | en |
| dc.relation.ispartof | Veterinary Research 2013, 44:83 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//AGL2010-22341-C04-01/ES/ | |
| dc.relation.publisherversion | https://dx.doi.org/10.1186/1297-9716-44-83 | |
| dc.rights | © 2013 Crespo et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/2.0/ | |
| dc.subject | Maedi Visna | en |
| dc.subject | Caprine arthritis-encephalitis | en |
| dc.subject | Colony-stimulating factor | en |
| dc.subject | In-vivo | en |
| dc.subject | Alveolar macrophages | en |
| dc.subject | Mannose receptor | en |
| dc.subject | Dendritic cell | en |
| dc.subject | Phylogenetic analysis | en |
| dc.subject | Nucleotide-sequence | en |
| dc.subject | Host-range | en |
| dc.title | Small ruminant macrophage polarization may play a pivotal role on lentiviral infection | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
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