Nano-photonic crystal D-shaped fiber devices for label-free biosensing at the attomolar limit of detection

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dc.contributor.authorDel Villar, Ignacio
dc.contributor.authorGonzález-Valencia, Esteban
dc.contributor.authorKwietniewski, Norbert
dc.contributor.authorBurnat, Dariusz
dc.contributor.authorArmas, Dayron
dc.contributor.authorPitula, Emil
dc.contributor.authorJanik, Monika
dc.contributor.authorMatías Maestro, Ignacio
dc.contributor.authorGiannetti, Ambra
dc.contributor.authorTorres, Pedro
dc.contributor.authorChiavaioli, Francesco
dc.contributor.authorSmietana, Mateusz
dc.contributor.departmentIngeniería Eléctrica, Electrónica y de Comunicaciónes_ES
dc.contributor.departmentIngeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritzaeu
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.date.accessioned2024-11-11T08:47:18Z
dc.date.available2024-11-11T08:47:18Z
dc.date.issued2024-07-23
dc.date.updated2024-11-11T08:38:33Z
dc.description.abstractMaintaining both high sensitivity and large figure of merit (FoM) is crucial in regard to the performance of optical devices, particularly when they are intended for use as biosensors with extremely low limit of detection (LoD). Here, a stack of nano-assembled layers in the form of 1D photonic crystal, deposited on D-shaped single-mode fibers, is created to meet these criteria, resulting in the generation of Bloch surface wave resonances. The increase in the contrast between high and low refractive index (RI) nano-layers, along with the reduction of losses, enables not only to achieve high sensitivity, but also a narrowed resonance bandwidth, leading to a significant enhancement in the FoM. Preliminary testing for bulk RI sensitivity is carried out, and the effect of an additional nano-layer that mimics a biological layer where binding interactions occur is also considered. Finally, the biosensing capability is assessed by detecting immunoglobulin G in serum at very low concentrations, and a record LoD of 70 aM is achieved. An optical fiber biosensor that is capable of attaining extraordinarily low LoD in the attomolar range is not only a remarkable technical outcome, but can also be envisaged as a powerful tool for early diagnosis of diseases.en
dc.description.sponsorshipThis research was funded in Spain by Agencia Estatal de Investigacion (PID2022-137437OB-I00) and Public University of Navarra predoctoral research grants. This work was partially funded by the Instituto Tecnológico Metropolitano, project P23210, the Universidad Nacional de Colombia, Facultad de Ciencias de la sede Medellín (Hermes code 56330). E.G.V. acknowledges the support of Minciencias through the Doctoral Scholarship program. This study was carried out within the 'Fiber optics sensors as a platform for cancer diagnosis and in vitro model testing' project - funded by European Union - Next Generation EU within the PRIN 2022 PNRR (P2022Y4TP5) program (D.D.1409 del 14/09/2022 Ministero dell'Università e della Ricerca). This manuscript reflects only the authors' views and opinions and the Ministry cannot be considered responsible for them. Financial support received from the National Science Centre (NCN), Poland, under grant No. 2019/35/B/ST7/04388 and in part by National Centre for Research and Development (NCBiR), Poland under grant No. TECHMATSTRATEG-III/0042/2019, was also acknowledged. Open Access provided by Universidad Pública de Navarra within the CRUI CARE Agreement.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDel Villar, I., Gonzalez-Valencia, E., Kwietniewski, N., Burnat, D., Armas, D., Pitura, E., Janik, M., Matías, I.R., Giannetti, A., Torres, P., Chiavaioli, F., Smietana, M. (2024). Nano-photonic crystal D-shaped fiber devices for label-free biosensing at the attomolar limit of detection. Advanced Science, 1-14. https://doi.org/10.1002/advs.202310118.
dc.identifier.doi10.1002/advs.202310118
dc.identifier.issn2198-3844
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/52477
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofAdvanced Science (2024), vol. 11, núm. 35
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-137437OB-I00/ES/
dc.relation.publisherversionhttps://doi.org/10.1002/advs.202310118
dc.rights© 2024 The Author(s). Advanced Science published by Wiley-VCHGmbH. This is an open access article under the terms of the Creative Commons Attribution License.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBloch surface waveen
dc.subjectLabel-free fiber-based biosensoren
dc.subjectLimit of detectionen
dc.subjectNano-photonic crystalen
dc.subjectThin filmsen
dc.titleNano-photonic crystal D-shaped fiber devices for label-free biosensing at the attomolar limit of detectionen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication4af62af3-50fe-47ee-a17c-bd4ffb52ebe3
relation.isAuthorOfPublication32ee548b-de78-4dc5-a5a8-6e71ee034ff1
relation.isAuthorOfPublicationbbb769e0-e56c-4b53-8e0b-cf33da20a35d
relation.isAuthorOfPublication.latestForDiscovery4af62af3-50fe-47ee-a17c-bd4ffb52ebe3

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