Experimental and theoretical studies of the interaction of ketoprofen in halloysite nanotubes

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dc.contributor.authorSid, Dounia
dc.contributor.authorBaitiche, Milad
dc.contributor.authorBourzami, Riahd
dc.contributor.authorMerir, Roufaida
dc.contributor.authorDjerboua, Ferhat
dc.contributor.authorGil Bravo, Antonio
dc.contributor.authorBoutahala, Mokhtar
dc.contributor.departmentZientziakeu
dc.contributor.departmentInstitute for Advanced Materials and Mathematics - INAMAT2en
dc.contributor.departmentCienciases_ES
dc.date.accessioned2022-01-26T08:35:07Z
dc.date.available2023-07-04T23:00:11Z
dc.date.issued2021
dc.description.abstractIn recent years, the application of halloysite (HAL) in the conception of drug systems has become important due to its excellent physicochemical properties. Ketoprofen (KET) is widely used around the world as an anti-inflammatory drug. A formulation of HAL-KET was prepared. The interaction between the KET molecules and HAL has been investigated experimentally by Zeta potential, TEM, XRD, FTIR spectroscopy and TGA/DSC. In addition, this interaction was studied theoretically by using Monte-Carlo calculation method (MC). The results have shown that the interaction of KET is stabilized not only by electrostatic interactions and hydrogen bonds with HAL but also via the delocalized π electrons density of phenyl groups of KET and the hydrogen atoms of HAL.en
dc.description.sponsorshipThis work was financially supported by la direction générale de la recherche scientifique (Algeria), le laboratoire de génie des procédés chimiques (LGPC) et le laboratoire des matériaux émergeants de l'université de Sétif 1. A.G also thanks Santander Bank (Navarra, Spain) for funding via the Research Intensification Program.en
dc.embargo.lift2023-07-04
dc.embargo.terms2023-07-04
dc.format.extent31 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDounia Sid, Milad Baitiche, Riadh Bourzami, Roufaida Merir, Ferhat Djerboua, Antonio Gil and Mokhtar Boutahala, Experimental and theoretical studies of the interaction of ketoprofen in halloysite nanotubes, Colloids and Surfaces A: Physicochemical and Engineering Aspects, (2021) doi:https://doi.org/10.1016/j.colsurfa.2021.127136en
dc.identifier.doi10.1016/j.colsurfa.2021.127136
dc.identifier.issn0927-7757
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/41949
dc.language.isoengen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces A: Physicochemical and Engineering Aspects, 627, 20 October 2021, 127136en
dc.relation.publisherversionhttps://doi.org/10.1016/j.colsurfa.2021.127136
dc.rights© 2021 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCharacterizationen
dc.subjectHalloysiteen
dc.subjectInteractionen
dc.subjectKetoprofenen
dc.subjectMolecular modelingen
dc.subjectPharmaceutical carrieren
dc.titleExperimental and theoretical studies of the interaction of ketoprofen in halloysite nanotubesen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationcd12e590-cb42-47d5-a642-f60eeee624ec
relation.isAuthorOfPublication.latestForDiscoverycd12e590-cb42-47d5-a642-f60eeee624ec

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