Effect of physical activity on cardiovascular event risk in a population-based cohort of patients with type 2 diabetes

Enguita Germán, Mónica; Tamayo Rodríguez, Ibai; Galbete Jiménez, Arkaitz; Librero, Julián; Cambra Contin, Koldo; Ibáñez Beroiz, Berta

Publication:
Effect of physical activity on cardiovascular event risk in a population-based cohort of patients with type 2 diabetes

dc.contributor.author	Enguita Germán, Mónica
dc.contributor.author	Tamayo Rodríguez, Ibai
dc.contributor.author	Galbete Jiménez, Arkaitz
dc.contributor.author	Librero, Julián
dc.contributor.author	Cambra Contin, Koldo
dc.contributor.author	Ibáñez Beroiz, Berta
dc.contributor.department	Estadística, Informática y Matemáticas	es_ES
dc.contributor.department	Estatistika, Informatika eta Matematika	eu
dc.date.accessioned	2022-04-06T11:59:47Z
dc.date.available	2022-04-06T11:59:47Z
dc.date.issued	2021
dc.description.abstract	Cardiovascular disease (CVD) is the most common cause of morbidity and mortality among patients with type 2 diabetes (T2D). Physical activity (PA) is one of the few modifiable factors that can reduce this risk. The aim of this study was to estimate to what extent PA can contribute to reducing CVD risk and all-cause mortality in patients with T2D. Information from a population-based cohort including 26,587 patients with T2D from the Navarre Health System who were fol-lowed for five years was gathered from electronic clinical records. Multivariate Cox regression models were fitted to estimate the effect of PA on CVD risk and all-cause mortality, and the approach was complemented using conditional logistic regression models within a matched nested case–con-trol design. A total of 5111 (19.2%) patients died during follow-up, which corresponds to 37.8% of the inactive group, 23.9% of the partially active group and 12.4% of the active group. CVD events occurred in 2362 (8.9%) patients, which corresponds to 11.6%, 10.1% and 7.6% of these groups. Compared with patients in the inactive group, and after matching and adjusting for confounders, the OR of having a CVD event was 0.84 (95% CI: 0.66–1.07) for the partially active group and 0.71 (95% CI: 0.56–0.91) for the active group. A slightly more pronounced gradient was obtained when focused on all-cause mortality, with ORs equal to 0.72 (95% CI: 0.61–0.85) and 0.50 (95% CI: 0.42–0.59), respectively. This study provides further evidence that physically active patients with T2D may have a reduced risk of CVD-related complications and all-cause mortality.	en
dc.description.sponsorship	Funding: this research was funded by the Instituto de Salud Carlos III, via grant PI15/02196 and via CONCEPT project (grants PI19/00154, PI19/00306, PI19/00381, PI19/00056 and PI20/00783). It also received funding from the Research Network on Health Services in Chronic Diseases (REDIS-SEC) grant RD16/0001/0014, a Spanish Network supported by Instituto de Salud Carlos III and the European Regional Development Funding (FEDER). All funds are public and had no role in the design of the study, the data integration and analysis or in the writing of the paper.	en
dc.format.extent	13 p.
dc.format.mimetype	application/pdf	en
dc.format.mimetype	application/zip	en
dc.identifier.doi	10.3390/ijerph182312370
dc.identifier.issn	1661-7827
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/42636
dc.language.iso	eng	en
dc.publisher	MDPI
dc.relation.ispartof	International Journal of Environmental Research and Public Health, 18 (23)	en
dc.relation.publisherversion	https://doi.org/10.3390/ijerph182312370
dc.rights	© 2021 by the authors. Creative Commons Attribution 4.0 International	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	Cardiovascular disease	en
dc.subject	Mortality	en
dc.subject	Nested case-control	en
dc.subject	Physical activity	en
dc.subject	Population-based cohort	en
dc.subject	Type 2 diabetes	en
dc.title	Effect of physical activity on cardiovascular event risk in a population-based cohort of patients with type 2 diabetes	en
dc.type	info:eu-repo/semantics/article	en
dc.type	Artículo / Artikulua	es
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dspace.entity.type	Publication
relation.isAuthorOfPublication	ea88491f-9642-4b5b-b1d7-02987d63fc1b
relation.isAuthorOfPublication	488f1d4a-17fc-4f8c-87c0-8939257c87d7
relation.isAuthorOfPublication	4bb570ab-10a2-4b9a-8ee8-893bbd090df6
relation.isAuthorOfPublication	965d0cdc-67d8-4ff2-805a-fd8e6b68e273
relation.isAuthorOfPublication	6cc547dc-8ec5-4b66-b920-358328d1f12c
relation.isAuthorOfPublication.latestForDiscovery	ea88491f-9642-4b5b-b1d7-02987d63fc1b