Gold nanoparticles capped with a novel titanium(iv)-containing polyoxomolybdate cluster: selective and enhanced bactericidal effect against Escherichia coli

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dc.contributor.authorPaesa, Mónica
dc.contributor.authorAlmazán, Fernando
dc.contributor.authorYus Argón, Cristina
dc.contributor.authorSebastián, Víctor
dc.contributor.authorArruebo Gordo, Manuel
dc.contributor.authorReinoso, Santiago
dc.contributor.authorPellejero, Ismael
dc.contributor.authorGandía Pascual, Luis
dc.contributor.authorMendoza, Gracia
dc.contributor.departmentCienciases_ES
dc.contributor.departmentZientziakeu
dc.contributor.departmentInstitute for Advanced Materials and Mathematics - INAMAT2en
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.date.accessioned2024-02-16T20:19:15Z
dc.date.available2024-02-16T20:19:15Z
dc.date.issued2024
dc.date.updated2024-02-16T19:58:52Z
dc.description.abstractBacterial infections are a public health threat of increasing concern in medical care systems; hence, the search for novel strategies to lower the use of antibiotics and their harmful effects becomes imperative. Herein, the antimicrobial performance of four polyoxometalate (POM)-stabilized gold nanoparticles (Au@POM) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as Gram-negative and Gram-positive bacteria models, respectively, is studied. The bactericidal studies performed, both in planktonic and sessile forms, evidence the antimicrobial potential of these hybrid nanostructures with selectivity toward Gram-negative species. In particular, the Au@GeMoTi composite with the novel [Ti2(HGeMo7O28)2]10¿ POM capping ligand exhibits outstanding bactericidal efficiency with a minimum inhibitory concentration of just 3.12 µm for the E. coli strain, thus outperforming the other three Au@POM counterparts. GeMoTi represents the fourth example of a water-soluble TiIV-containing polyoxomolybdate, and among them, the first sandwich-type structure having heteroatoms in high-oxidation state. The evaluation of the bactericidal mechanisms of action points to the cell membrane hyperpolarization, disruption, and subsequent nucleotide leakage and the low cytotoxicity exerted on five different cell lines at antimicrobial doses demonstrates the antibiotic-like character. These studies highlight the successful design and development of a new POM-based nanomaterial able to eradicate Gram-negative bacteria without damaging mammalian cells.en
dc.description.sponsorshipThe authors thank the following institutions for the financial support to carry out this research: Spanish Ministerio de Ciencia e Innovación,Spanish Agencia Estatal de Investigación, and FEDER “una manera dehacer Europa” (grant numbers PID2020-113987RB-I00, PDC2021-121405-I00, PID2019-106687RJ-I00, and PID2021-127265OB-C21); Gobierno de Navarra (grant number PC091-092 FOREST2+). CIBER-BBN is an initia-tive funded by the VI National R&D&i Plan 2008–2011 financed by the In-stituto de Salud Carlos III with the assistance of the European Regional Development Fund. M.P. acknowledges the support from Gobierno de Aragón (Orden CUS/581/2020). G.M. gratefully acknowledges the sup-port from the Miguel Servet Program (MS19/00092; Instituto de SaludCarlos III). Open access funding is provided by Universidad Pública de Navarra.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPaesa, M., Almazán, F., Yus, C., Sebastián, V., Arruebo, M., Gandía, L. M., Reinoso, S., Pellejero, I., Mendoza, G. (2024) Gold nanoparticles capped with a novel titanium(iv)-containing polyoxomolybdate cluster: Selective and enhanced bactericidal effect against Escherichia coli. Small, 20(6), 1-13. https://doi.org/10.1002/smll.202305169.en
dc.identifier.doi10.1002/smll.202305169
dc.identifier.issn1613-6810
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/47502
dc.language.isoengen
dc.publisherWileyen
dc.relation.ispartofSmall, 20(6), 2024, 2305169en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113987RB-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121405-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106687RJ-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127265OB-C21/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//PC091-092 FOREST2+/
dc.relation.publisherversionhttps://doi.org/10.1002/smll.202305169
dc.rights© 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAntimicrobialen
dc.subjectCytotoxicityen
dc.subjectEscherichia colien
dc.subjectGold nanoparticlesen
dc.subjectPathogenic bacteriaen
dc.subjectPolyoxometalatesen
dc.titleGold nanoparticles capped with a novel titanium(iv)-containing polyoxomolybdate cluster: selective and enhanced bactericidal effect against Escherichia colien
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication46bbf241-764d-4c78-9667-4c307cf84092
relation.isAuthorOfPublicationb4cb3430-7b46-428d-8714-7d9af415aebf
relation.isAuthorOfPublicationd2bd5a4b-ea1f-488b-afea-05b77f69d3f0
relation.isAuthorOfPublication.latestForDiscovery46bbf241-764d-4c78-9667-4c307cf84092

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