Measurement of paracetamol concentration using an erbium-doped fiber ring cavity
| dc.contributor.author | Soares, Liliana | |
| dc.contributor.author | Pérez Herrera, Rosa Ana | |
| dc.contributor.author | Novais, Susana | |
| dc.contributor.author | Ferreira, António | |
| dc.contributor.author | Silva, Susana | |
| dc.contributor.author | Frazão, Orlando | |
| dc.contributor.department | Ingeniería Eléctrica, Electrónica y de Comunicación | es_ES |
| dc.contributor.department | Institute of Smart Cities - ISC | en |
| dc.contributor.department | Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren | eu |
| dc.date.accessioned | 2023-04-28T17:53:28Z | |
| dc.date.available | 2023-04-28T17:53:28Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2023-04-28T17:44:01Z | |
| dc.description.abstract | Process Analytical Technology (PAT) has been increasingly used in the pharmaceutical industry to monitor essential parameters in real-time during pharmaceutical processes. The concentration of Active Pharmaceutical Ingredients (APIs), such as paracetamol, is one of these parameters, and controlling its variations allows for optimization of the production process. In this study, a refractometric sensor, implemented by an interrogation system based on an Erbium-Doped Fiber Ring Cavity (EDFRC), was presented and experimentally demonstrated. The Cavity Ring proposed included a 1 × 3 coupler. One port of the coupler was used to increase the optical power of the system through a Fiber Bragg Grating (FBG), and the other two ports were used as sensing head and reference. The sensor detected variations of paracetamol concentration with a sensitivity of [(−1.00 ± 0.05) × 10−3] nW/(g/kg) and a resolution of 5.53 g/kg. The results demonstrate the potential of this technology as a possible non-invasive PAT tool. | en |
| dc.description.sponsorship | and European Union “Next generation EU”/PTR. Liliana Soares acknowledges the support of FCT, Portugal, through the Grant 2020.05297.BD.This research was funded by: National Funds through the Portuguese funding agency, FCT—Fundação para a Ciência e a Tecnologia, within project UIDB/50014/2020; National Funds through FCT/MCTES (PIDDAC), within projects LA/P/0045/2020 (ALiCE), UIDB/00511/2020, and UIDP/00511/2020 (LEPABE); Program “José Castillejo para estancias de movilidad en el extranjero de jóvenes doctores”, funded by the Ministerio de Univesidades of Spain (reference CAS21/00351); project PID2019-107270RB-C22, funded by MCIN/AEI/10.13039/501100011033 and FEDER “A way to make Europe”; projects PDC2021-121172-C21 and TED2021-130378B-C22, funded by MCIN/AEI/10.13039/501100011033 | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Soares, L., Pérez-Herrera, R. A., Novais, S., Ferreira, A., Silva, S., & Frazão, O. (2023). Measurement of paracetamol concentration using an erbium-doped fiber ring cavity. Photonics, 10(1), 50. https://doi.org/10.3390/photonics10010050 | en |
| dc.identifier.doi | 10.3390/photonics10010050 | |
| dc.identifier.issn | 2304-6732 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/45191 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | en |
| dc.relation.ispartof | Photonics 2023, 10(1), 50 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement///CAS21%2F00351/ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107270RB-C22/ES/ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI//PDC2021-121172-C21/ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI//TED2021-130378B-C22/ | |
| dc.relation.publisherversion | https://doi.org/10.3390/photonics10010050 | |
| dc.rights | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Concentration | en |
| dc.subject | Erbium-doped fiber | en |
| dc.subject | Paracetamol | en |
| dc.subject | Process analytical technology | en |
| dc.subject | Ring cavity | en |
| dc.title | Measurement of paracetamol concentration using an erbium-doped fiber ring cavity | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | a79291e5-5f2e-4f57-89d3-aceda724e949 | |
| relation.isAuthorOfPublication.latestForDiscovery | a79291e5-5f2e-4f57-89d3-aceda724e949 |