Towards precision prognostication and personalized therapeutics through proteomics
Fecha
2023Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Otros / Bestelakoak
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
Impacto
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10.3390/ijms24076361
Resumen
Next-generation proteomics has allowed the implementation of biomedical proteome research to uncover disease-affected protein expression profiles. It has also enabled the determination of protein localization, protein interactomes, posttranslational modifications and protein dysfunction in human diseases. Many pillars in personalized medicine, such as diagnostic improvements, drug screening, syst ...
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Next-generation proteomics has allowed the implementation of biomedical proteome research to uncover disease-affected protein expression profiles. It has also enabled the determination of protein localization, protein interactomes, posttranslational modifications and protein dysfunction in human diseases. Many pillars in personalized medicine, such as diagnostic improvements, drug screening, systems biology or bioinformatics, require the generation of quantitatively consistent proteomics data from translational animal models to human biospecimens to fill the information gap, making omics analysis actionable from a clinical perspective [1-3]. This Special Issue received multiple submissions, of which five original articles were accepted for publication. These contributions cover different phases of precision medicine in the context of proteomics: (i) discovery and quantitation of potential biomarker candidates (three articles), (ii) the proteostatic modulation and mechanisms of action of pharmacological compounds (one article) and (iii) the characterization of posttranslational modifications (one article). [--]
Materias
Proteomics,
Prognostication
Editor
MDPI
Publicado en
International Journal of Molecular Sciences, 2023, 24(7), 6361
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
This work was funded by grants from the Spanish Ministry of Science, Innovation and
Universities (Ref. PID2019-110356RB-I00/AEI/10.13039/501100011033) and the Department of
Economic and Business Development from Government of Navarra (Ref. 0011-1411-2020-000028).