Listar por autor "Santamaría, Enrique"
Mostrando ítems 41-57 de 57
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The proteome of Medicago truncatula in response to ammonium and urea nutrition reveals the role of membrane proteins and enzymes of root lignification
Royo Castillejo, Beatriz
; Esteban Terradillos, Raquel; Buezo Bravo, Javier ; Santamaría, Enrique; Fernández Irigoyen, Joaquín 
; Becker, Dirk; Morán Juez, José Fernando (Elsevier, 2019)
Artículo / Artikulua 
Plants differ widely in their growth and tolerance responses to ammonium and urea nutrition, while derived phenotypes seem markedly different from plants grown under nitrate supply. Plant responses to N sources are complex, ... -
Proteomic and functional characterisation of extracellular vesicles from collagen VI deficient human fibroblasts reveals a role in cell motility
(Springer, 2023) Artículo / Artikulua
Extracellular vesicles (EVs) are key mediators of cell-to-cell communication. Their content reflects the state of diseased cells representing a window into disease progression. Collagen-VI Related Muscular Dystrophy (COL6-RD) ... -
A proteomic atlas of lineage and cancer-polarized expression modules in myeloid cells modeling immunosuppressive tumor-infiltrating subsets
Blanco, Ester; Ibáñez-Vea, María ; Hernández, Carlos; Drici, Lylia; Martínez de Morentin Iribarren, Xabier; Gato Cañas, María; Ausín, Karina; Bocanegra Gondán, Ana Isabel; Zuazo Ibarra, Miren ; Chocarro, Luisa ; Arasanz Esteban, Hugo; Fernández Hinojal, Gonzalo; Fernández Irigoyen, Joaquín ; Smerdou, Cristian; Garnica, Maider; Echaide Górriz, Míriam; Fernández Rubio, Leticia; Morente Sancho, Pilar; Ramos-Castellanos, Pablo; Llopiz, Diana; Santamaría, Enrique; Larsen, Martin R.; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2021)
Artículo / Artikulua
Monocytic and granulocytic myeloid-derived suppressor cells together with tumor-infiltrating macrophages constitute the main tumor-infiltrating immunosuppressive myeloid populations. Due to the phenotypic resemblance to ... -
Proteostatic modulation in brain aging without associated Alzheimer's disease-and age-related neuropathological changes
Andrés Benito, Pol; Íñigo-Marco, Ignacio; Brullas, Marta; Carmona, Margarita; Del Rio, José Antonio; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Povedano, Mónica; Ferrer, Isidro (Impact Journals, 2023)
Artículo / Artikulua
Aims: (Phospho)proteomics of old-aged subjects without cognitive or behavioral symptoms, and without ADneuropathological changes and lacking any other neurodegenerative alteration will increase understanding about the ... -
Pyk2 regulates MAMs and mitochondrial dynamics in hippocampal neurons
López-Molina, Laura; Fernández Irigoyen, Joaquín ; Cifuentes-Díaz, Carmen; Alberch, Jordi; Girault, Jean Antoine; Santamaría, Enrique; Ginés, Silvia; Giralt, Albert (MDPI, 2022)
Artículo / Artikulua
Pyk2 is a non-receptor tyrosine kinase enriched in hippocampal neurons, which can be activated by calcium-dependent mechanisms. In neurons, Pyk2 is mostly localised in the cytosol and dendritic shafts but can translocate ... -
Quantitative proteomics reveals the importance of nitrogen source to control glucosinolate metabolism in Arabidopsis thaliana and Brassica oleracea
Marino Bilbao, Daniel ; Ariz, Idoia ; Lasa Larrea, Berta; Santamaría, Enrique; Aparicio Tejo, Pedro María (Oxford University Press, 2016)
Artículo / Artikulua
Accessing different nitrogen (N) sources involves a profound adaptation of plant metabolism. In this study, a quantitative proteomic approach was used to further understand how the model plant Arabidopsis thaliana adjusts ... -
The regulators of peroxisomal acyl-carnitine shuttle CROT and CRAT promote metastasis in melanoma
Lasheras Otero, Irene; Feliu, Iker; Maíllo Ruiz de Infante, Alberto; Moreno, Haritz; Redondo Muñoz, Marta; Aldaz Donamaría, Paula; Bocanegra Gondán, Ana Isabel; Olías Arjona, Ana; Lecanda, Fernando; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Larráyoz, Ignacio M.; Gómez Cabrero, David; Wellbrock, Claudia; Vicent, Silvestre; Arozarena Martinicorena, Imanol (Elsevier, 2023)
Artículo / Artikulua
Circulating tumor cells are the key link between a primary tumor and distant metastases, but once in the bloodstream, loss of adhesion induces cell death. To identify the mechanisms relevant for melanoma circulating tumor ... -
Revisión bibliográfica del efecto del entrenamiento en mujeres con esclerosis múltiple: inclusión de mediciones del sistema inmune como propuesta de investigación. Revisión bibliográfica y propuesta de investigación.
(2023) Trabajo Fin de Grado/Gradu Amaierako Lana
Antecedentes: la EM es una enfermedad autoinmune y desmielinizante del SNC, que produce una sintomatología variada, la cual abarca el aspecto físico, psicológico y cognitivo. Esta enfermedad, produce una gran decadencia ... -
RTP801 mediates transneuronal toxicity in culture via extracellular vesicles
Solana-Balaguer, Júlia; Martín-Flores, Núria; García-Segura, Pol; Campoy-Campos, Genís; Pérez-Sisqués, Leticia; Chicote-González, Almudena; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Pérez-Navarro, Esther; Alberch, Jordi; Malagelada, Cristina (Wiley, 2023)
Artículo / Artikulua
Extracellular vesicles (EVs) play a crucial role in intercellular communication, participating in the paracrine trophic support or in the propagation of toxic molecules, including proteins. RTP801 is a stress-regulated ... -
Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory-entorhinal-amygdaloid axis in Alzheimer's and Parkinson's diseases
Cartas-Cejudo, Paz; Lachén Montes, Mercedes ; Ferrer, Isidro; Fernández Irigoyen, Joaquín; Santamaría, Enrique (BMC, 2023)
Artículo / Artikulua
Background Smell impairment is one of the earliest features in Alzheimer’s (AD) and Parkinson’s diseases (PD). Due to sex diferences exist in terms of smell and olfactory structures as well as in the prevalence and ... -
Sex-specific role of galectin-3 in aortic stenosis
Matilla Cuenca, Lara; Martín Núñez, Ernesto; Garaikoetxea Zubillaga, Mattie; Navarro, Adela; Tamayo Rodríguez, Ibai; Fernández Celis, Amaya; Gaínza Calleja, Alicia; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Muntendam, Pieter; Álvarez, Virginia; Sádaba Sagredo, Rafael; Jover, Eva; López Andrés, Natalia (BMC, 2023)
Artículo / Artikulua
Background: Aortic stenosis (AS) is characterized by infammation, fbrosis, osteogenesis and angiogenesis. Men and women develop these mechanisms diferently. Galectin-3 (Gal-3) is a pro-infammatory and pro-osteogenic lectin ... -
Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism
Lachén Montes, Mercedes ; Mendizuri, Naroa; Ausín, Karina; Pérez Mediavilla, Alberto; Azkargorta, Mikel; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Iloro, Ibon; Elortza, Félix; Kondo, Hiroyuki; Ohigashi, Izumi; Ferrer, Isidro; Torre, Rafael de la; Robledo, Patricia (ACS Publications, 2020)
Artículo / Artikulua
The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining ... -
Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models
Vinueza-Gavilanes, Rodrigo; Bravo-González, Jorge Juan; Basurco, Leyre; Boncristiani, Chiara; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Marcilla, Irene; Pérez Mediavilla, Alberto; Luquin, María Rosario; Vales, Africa; González-Aseguinolaza, Gloria; Aymerich, María Soledad; Aragón, Tomás; Arrasate, Montserrat (Elsevier, 2023)
Artículo / Artikulua
Synucleinopathies are a group of neurodegenerative diseases without effective treatment characterized by the abnormal aggregation of alpha-synuclein (aSyn) protein. Changes in levels or in the amino acid sequence of aSyn ... -
Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism
Merino Galán, Leyre; Jiménez Urbieta, Haritz; Zamarbide, Marta; Rodríguez Chinchilla, Tatiana; Belloso Iguerategui, Arantzazu; Santamaría, Enrique; Fernández Irigoyen, Joaquín ; Aiastui, Ana; Doudnikoff, Evelyne.; Bézard, Erwan; Ouro, Alberto; Knafo, Shira; Gago, Belén; Quiroga Varela, Ana; Rodríguez Oroz, María Cruz (Oxford University Press, 2022)
Artículo / Artikulua
Synaptic impairment might precede neuronal degeneration in Parkinson’s disease. However, the intimate mechanisms altering synaptic function by the accumulation of presynaptic α-synuclein in striatal dopaminergic terminals ... -
Tackling the biological meaning of the human olfactory bulb dyshomeostatic proteome across neurological disorders: an integrative bioinformatic approach
Cartas-Cejudo, Paz; Lachén Montes, Mercedes ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2021)
Artículo / Artikulua
Olfactory dysfunction is considered an early prodromal marker of many neurodegenerative diseases. Neuropathological changes and aberrant protein aggregates occur in the olfactory bulb (OB), triggering a tangled cascade of ... -
Towards precision prognostication and personalized therapeutics through proteomics
(MDPI, 2023) Otros / Bestelakoak
Next-generation proteomics has allowed the implementation of biomedical proteome research to uncover disease-affected protein expression profiles. It has also enabled the determination of protein localization, protein ... -
Ultrahigh sensitive detection of tau protein as Alzheimer's biomarker via microfluidics and nanofunctionalized optical fiber sensors
Chiavaioli, Francesco; Santano, Desiree ; Del Villar, Ignacio ; Socorro Leránoz, Abián Bentor ; Zhang, Xuejun; Li, Kaiwei; Santamaría, Enrique; Fernández Irigoyen, Joaquín ; Baldini, Francesco; Van den Hove, Daniel L. A.; Shi, Lei; Bi, Wei; Guo, Tuan; Giannetti, Ambra; Matías Maestro, Ignacio (Wiley, 2022)
Artículo / Artikulua
Alzheimer’s disease (AD) is one of the most common neurodegenerative illnesses displaying the highest death rate in the elderly. However, the existing AD diagnostic system remains elusive due to lack of a technology that ...
