Listar por autor "Córdoba Iturriagagoitia, Alicia"
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ADAM12 is a potential therapeutic target regulated by hypomethylation in triple-negative breast cancer
Mendaza Lainez, Saioa ; Ulazia Garmendia, Ane; Monreal Santesteban, Iñaki; Córdoba Iturriagagoitia, Alicia; Ruiz de Azúa, Yerani (MDPI, 2020) Artículo / ArtikuluaTriple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and currently lacks any effective targeted therapy. Since epigenetic alterations are a common event in TNBC, DNA methylation profiling can ... -
CDH22 hypermethylation is an independent prognostic biomarker in breast cancer
Martín Sánchez, Esperanza; Mendaza Lainez, Saioa ; Ulazia Garmendia, Ane; Monreal Santesteban, Iñaki; Córdoba Iturriagagoitia, Alicia; Vicente García, Francisco; Blanco Luquin, Idoia; Cruz, Susana de la; Aramendia, Ana; Guerrero Setas, David (BioMed Central, 2017) Artículo / ArtikuluaBackground: Cadherin-like protein 22 (CDH22) is a transmembrane glycoprotein involved in cell-cell adhesion and metastasis. Its role in cancer is controversial because it has been described as being upregulated in ... -
CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer
Martín Sánchez, Esperanza; Mendaza Lainez, Saioa ; Ulazia Garmendia, Ane; Monreal Santesteban, Iñaki; Blanco Luquin, Idoia; Córdoba Iturriagagoitia, Alicia; Vicente García, Francisco; Pérez Janices, Noemi; Escors Murugarren, David; Megías, Diego (Impact Journals, 2017) Artículo / ArtikuluaThe CHL1 gene encodes a cell-adhesion molecule proposed as being a putative tumour-suppressor gene in breast cancer (BC). However, neither the underlying molecular mechanisms nor the clinical value of CHL1 downregulation ... -
Clinical, histopathologic and genetic features of rhabdoid meningiomas
Garrido Ruiz, Patricia Alejandra; González-Tablas, María; Pasco Peña, Alejandro; Zelaya Huerta, María Victoria ; Ortiz, Javier; Otero, Álvaro; Corchete, Luis Antonio; Ludeña, María Dolores; Caballero Martínez, María Cristina; Córdoba Iturriagagoitia, Alicia; Fernández, Inmaculada Catalina; González-Carreró Fojón, Joaquín; Hernández Laín, Aurelio; Orfao, Alberto; Tabernero, María Dolores (MDPI, 2023) Artículo / ArtikuluaRhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a ... -
A DNA methylation-based gene signature can predict triple-negative breast cancer diagnosis
Mendaza Lainez, Saioa ; Guerrero Setas, David; Monreal Santesteban, Iñaki; Ulazia Garmendia, Ane; Córdoba Iturriagagoitia, Alicia; Cruz, Susana de la; Martín Sánchez, Esperanza (MDPI, 2021) Artículo / ArtikuluaTriple-negative breast cancer (TNBC) is the most aggressive breast cancer (BC) subtype and lacks targeted treatment. It is diagnosed by the absence of immunohistochemical expression of several biomarkers, but this method ... -
Subtipos moleculares del cáncer de mama: implicaciones pronósticas y características clínicas e inmunohistoquímicas
Arrechea Irigoyen, María Asunción; Vicente García, Francisco; Córdoba Iturriagagoitia, Alicia; Ibáñez Beroiz, B. ; Santamaría Martínez, M.; Guillén Grima, Francisco (Gobierno de Navarra, 2011) Artículo / ArtikuluaFundamento. Los carcinomas de mama representan un grupo heterogéneo de tumores, tanto en su comportamiento clínico como pronóstico. El objetivo del presente trabajo es clasificar los carcinomas de mama en subtipos ... -
ZEB1 hypermethylation is associated with better prognosis in patients with colon cancer
Fernández de los Reyes, Irene; Gómez Dorronsoro, María Luisa; Monreal Santesteban, Iñaki; Fernández-Fernández, Agustín; Fraga, Mario; Azcue Sanromán, Pablo; Alonso, Laura; Fernández-Marlasca, Beatriz; Suárez Alecha, Javier; Córdoba Iturriagagoitia, Alicia; Guerrero Setas, David (BMC, 2023) Artículo / ArtikuluaBackground: Colon cancer (CC) is a heterogeneous disease that is categorized into four Consensus Molecular Subtypes (CMS) according to gene expression. Patients with loco-regional CC (stages II/III) lack prognostic factors, ...