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Novel methylselenoesters as antiproliferative agents
(MDPI, 2017)
Artículo / Artikulua,
Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH3SeH) being one of the key executors. In this ...
Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment
(Public Library of Science, 2013)
info:eu-repo/semantics/article,
To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA
or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers ...
A diphenyldiselenide derivative induces autophagy via JNK in HTB-54 lung cancer cells
(Wiley, 2017)
info:eu-repo/semantics/article,
Symmetric aromatic diselenides are potential anticancer agents with strong cytotoxic activity. In this study, the in vitro anticancer activities of a novel series of diarylseleno derivatives from the diphenyldiselenide ...
Novel selenadiazole derivatives as selective antitumor and radical scavenging agents
(Elsevier, 2018)
info:eu-repo/semantics/article,
Twenty-seven novel benzo[c][1,2,5]selenadiazole-5-carboxylic acid (BSCA) derivatives were designed and synthesized. Anti-proliferative activity of these structures was tested in vitro against a panel of five human cancer ...
A fermented food product containing lactic acid bacteria protects ZDF rats from the development of type 2 diabetes
(MDPI, 2019)
info:eu-repo/semantics/article,
Type 2 diabetes (T2D) is a complex metabolic disease, which involves a maintained hyperglycemia due to the development of an insulin resistance process. Among multiple risk factors, host intestinal microbiota has received ...
Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells
(Elsevier, 2011)
info:eu-repo/semantics/article,
Type 11 Hydroxysteroid (17-beta) dehydrogenase (HSD17B11) catalyzes the conversion of 5α-androstan-3α,17β-diol into androsterone suggesting that it may play an important role in androgen metabolism. We previously described ...
Organoseleno cytostatic derivatives: autophagic cell death with AMPK and JNK activation
(Elsevier Masson SAS, 2019)
info:eu-repo/semantics/article,
Selenocyanates and diselenides are potential antitumor agents. Here we report two series of selenium derivatives related to selenocyanates and diselenides containing carboxylic, amide and imide moieties. These compounds ...