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Progressive modulation of the human olfactory bulb transcriptome during Alzheimer´s disease evolution: novel insights into the olfactory signaling across proteinopathies
(Impact Journals, 2017)
info:eu-repo/semantics/article,
Alzheimer´s disease (AD) is characterized by progressive dementia, initially
presenting olfactory dysfunction. Despite the olfactory bulb (OB) is the first central
structure of the olfactory pathway, we lack a complete ...
Network-driven proteogenomics unveils an aging-related imbalance in the olfactory IκBα-NFκB p65 complex functionality in Tg2576 Alzheimer’s disease mouse model
(MDPI, 2017)
info:eu-repo/semantics/article,
Olfaction is often deregulated in Alzheimer’s disease (AD) patients, and is also impaired
in transgenic Tg2576 AD mice, which overexpress the Swedish mutated form of human amyloid
precursor protein (APP). However, little ...
Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression
(Springer Nature, 2017)
info:eu-repo/semantics/article,
Olfactory dysfunction is among the earliest features of Alzheimer’s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- ...