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Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis
(MDPI, 2020)
info:eu-repo/semantics/article,
Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to ...
Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism
(ACS Publications, 2020)
info:eu-repo/semantics/article,
The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining ...
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions
(Frontiers Media, 2022)
Artículo / Artikulua,
One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role over ...
New in vivo approach to broaden the thioredoxin family interactome in chloroplasts
(MDPI, 2022)
Artículo / Artikulua,
Post-translational redox modifications provide an important mechanism for the control of major cellular processes. Thioredoxins (Trxs), which are key actors in this regulatory mechanism, are ubiquitous proteins that catalyse ...
Ultrahigh sensitive detection of tau protein as Alzheimer's biomarker via microfluidics and nanofunctionalized optical fiber sensors
(Wiley, 2022)
Artículo / Artikulua,
Alzheimer’s disease (AD) is one of the most common neurodegenerative illnesses
displaying the highest death rate in the elderly. However, the existing AD
diagnostic system remains elusive due to lack of a technology that ...
Fiber-based label-free D-dimer detection for early diagnosis of venous thromboembolism
(SPIE, 2020)
info:eu-repo/semantics/conferenceObject,
D-dimer is a useful diagnostic biomarker for deep vein thrombosis or pulmonary embolism, collectively referred to as venous thromboembolism (VTE). The ability to detect in real-time the amount of D-dimer with a fast and ...
Amyloid-driven tau accumulation on mitochondria potentially leads to cognitive deterioration in Alzheimer’s disease
(MDPI, 2021)
info:eu-repo/semantics/article,
Despite the well-accepted role of the two main neuropathological markers (β-amyloid and tau) in the progression of Alzheimer’s disease, the interaction and specific contribution of each of them is not fully elucidated. To ...
Altered cortical palmitoylation induces widespread molecular disturbances in Parkinson's disease
(MDPI, 2022)
Artículo / Artikulua,
The relationship between Parkinson’s disease (PD), the second-most common neurodegenerative disease after Alzheimer’s disease, and palmitoylation, a post-translational lipid modification,
is not well understood. In this ...
Striatal synaptic bioenergetic and autophagic decline in premotor experimental parkinsonism
(Oxford University Press, 2022)
Artículo / Artikulua,
Synaptic impairment might precede neuronal degeneration in Parkinson’s disease. However, the intimate mechanisms
altering synaptic function by the accumulation of presynaptic α-synuclein in striatal dopaminergic terminals ...
Maraviroc prevents hcc development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model
(MDPI, 2021)
info:eu-repo/semantics/article,
Maraviroc (MVC), a CCR5 antagonist, reduces liver fibrosis, injury and tumour burden in mice fed a hepatocarcinogenic diet, suggesting it has potential as a cancer therapeutic. We investigated the effect of MVC on liver ...