• Characterization of ovine A3Z1 restriction properties against small ruminant lentiviruses (SRLVs) 

      Pablo Maiso, Lorena de Upna Orcid; Glaría Ezquer, Idoia Upna; Crespo, Helena Upna; Nistal Villán, Estanislao; Andrésdóttir, Valgerdur; Andrés Cara, Damián de Upna Orcid; Amorena Zabalza, Beatriz Upna; Reina Arias, Ramsés Upna Orcid (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      Intrinsic factors of the innate immune system include the apolipoprotein B editing enzyme catalytic polypeptide-like 3 (APOBEC3) protein family. APOBEC3 inhibits replication of different virus families by cytosine ...
    • Detection of PrPSc in lung and mammary gland is favored by the presence of Visna/maedi virus lesions in naturally coinfected sheep 

      Salazar, Eider; Monleón, Eva; Bolea, Rosa; Acín, Cristina; Pérez, Marta María; Álvarez, Neila; Leginagoikoa, Iratxe; Juste, Ramón; Minguijón, Esmeralda; Reina Arias, Ramsés Upna Orcid; Glaría Ezquer, Idoia Upna; Berriatua, Eduardo; Andrés Cara, Damián de Upna Orcid; Badiola, Juan José; Amorena Zabalza, Beatriz Upna; Luján, Lluís (EDP Sciences, 2010)   Artículo / Artikulua  OpenAccess
      There are few reports on the pathogenesis of scrapie (Sc) and Visna/maedi virus (VMV) coinfections. The aim of this work was to study in vivo as well as post mortem both diseases in 91 sheep. Diagnosis of Sc and VMV ...
    • Diagnosing infection with small ruminant lentiviruses of genotypes A and B by combining synthetic peptides in ELISA 

      Sanjosé, Leticia; Crespo, Helena Upna; Glaría Ezquer, Idoia Upna; Andrés Cara, Damián de Upna Orcid; Reina Arias, Ramsés Upna Orcid (Elsevier, 2015)   Artículo / Artikulua  OpenAccess
      The major challenges in diagnosing small ruminant lentivirus (SRLV) infection include early detection and genotyping of strains of epidemiological interest. A longitudinal study was carried out in Rasa Aragonesa sheep ...
    • Expression analysis of lung miRNAs responding to ovine VM virus infection by RNA-seq 

      Bilbao Arribas, Martin; Abendaño, Naiara; Varela Martínez, Endika; Reina Arias, Ramsés Upna Orcid; Andrés Cara, Damián de Upna Orcid; Jugo, Begoña M. (BioMed Central, 2019)   Artículo / Artikulua  OpenAccess
      Background: MicroRNAs (miRNAs) are short endogenous, single-stranded, noncoding small RNA molecules of approximately 22 nucleotides in length. They regulate gene expression posttranscriptionally by silencing mRNA expression, ...
    • Growth performance and clinicopathological analyses in lambs repetitively inoculated with aluminum-hydroxide containing vaccines or aluminum-hydroxide only 

      Miguel, Ricardo de; Asín, Javier; Rodríguez Largo, Ana; Echeverría Garín, Irache Upna Orcid; Lacasta, Delia; Andrés Cara, Damián de Upna Orcid; Reina Arias, Ramsés Upna Orcid; Pinczowski, Pedro; Gimeno, Marina; Molín, Jéssica; Fernández, Antonio; Blas, Ignacio de; Pérez, Marta María; Luján, Lluís (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep— the so-called ovine autoimmune-inflammatory ...
    • Identification of the ovine mannose receptor and its possible role in Visna/Maedi virus infection 

      Crespo, Helena Upna; Reina Arias, Ramsés Upna Orcid; Glaría Ezquer, Idoia Upna; Ramírez, Hugo Upna Orcid; Andrés, Ximena de; Jauregui, Paula; Luján, Lluís; Martínez Pomares, Luisa; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna Orcid (BioMed Central, 2011)   Artículo / Artikulua  OpenAccess
      This study aims to characterize the mannose receptor (MR) gene in sheep and its role in ovine visna/maedi virus (VMV) infection. The deduced amino acid sequence of ovine MR was compatible with a transmembrane protein having ...
    • Immunization against small ruminant lentiviruses 

      Reina Arias, Ramsés Upna Orcid; Andrés Cara, Damián de Upna Orcid; Amorena Zabalza, Beatriz Upna (MDPI, 2013)   Artículo / Artikulua  OpenAccess
      Multisystemic disease caused by Small Ruminant Lentiviruses (SRLV) in sheep and goats leads to production losses, to the detriment of animal health and welfare. This, together with the lack of treatments, has triggered ...
    • Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers 

      Salazar, Eider; Berriatua, Eduardo; Pérez, Marta María; Marín, Belén; Acín, Cristina; Martín Burriel, Inmaculada; Reina Arias, Ramsés Upna Orcid; Andrés Cara, Damián de Upna Orcid; Amorena Zabalza, Beatriz Upna; Badiola, Juan José; Luján, Lluís (Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA), 2014)   Artículo / Artikulua  OpenAccess
      The relationship between Visna/maedi virus (VMV) antibody status and scrapie genetic resistance of 10,611 Rasa Aragonesa sheep from 17 flocks in Aragón (Spain) was investigated. The fifteen most common PRNP gene haplotypes and ...
    • Lentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbit 

      Crespo, Helena Upna; Guillén, Hugo; Pablo Maiso, Lorena de Upna Orcid; Gómez Arrebola, Carmen Upna Orcid; Rodríguez, Gregorio; Glaría Ezquer, Idoia Upna; Andrés Cara, Damián de Upna Orcid; Reina Arias, Ramsés Upna Orcid (Taylor & Francis, 2017)   Artículo / Artikulua  OpenAccess
      β-glucans exhibited in cell walls of several pathogens as bacteria or fungi are sensed by pathogen recognition receptors such as scavenger receptors present in antigen presenting cells, i.e., macrophages. β-glucans obtained ...
    • Mannose receptor may be involved in small ruminant lentivirus pathogenesis 

      Crespo, Helena Upna; Jauregui, Paula; Glaría Ezquer, Idoia Upna; Sanjosé, Leticia; Polledo, Laura; García Marín, Juan F.; Luján, Lluís; Andrés Cara, Damián de Upna Orcid; Amorena Zabalza, Beatriz Upna; Reina Arias, Ramsés Upna Orcid (BioMed Central, 2012)   Artículo / Artikulua  OpenAccess
      Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) ...
    • Molecular signature of aluminum hydroxide adjuvant in ovine PBMCs by integrated mRNA and microRNA transcriptome sequencing 

      Varela Martínez, Endika; Abendaño, Naiara; Asín, Javier; Sistiaga Poveda, Maialen; Pérez, Marta María; Reina Arias, Ramsés Upna Orcid; Andrés Cara, Damián de Upna Orcid; Luján, Lluís; Jugo, Begoña M. (Frontiers Media, 2018)   Artículo / Artikulua  OpenAccess
      There have been few in vivo studies on the effect of aluminum hydroxide adjuvant and its influence on the immune response to vaccination. In this study, lambs received a parallel subcutaneous treatment with either commercial ...
    • Ovine TRIM5α can restrict visna/maedi virus 

      Jauregui, Paula; Crespo, Helena Upna; Glaría Ezquer, Idoia Upna; Luján, Lluís; Contreras, A.; Rosati, Sergio; Andrés Cara, Damián de Upna Orcid; Amorena Zabalza, Beatriz Upna; Towers, G. J.; Reina Arias, Ramsés Upna Orcid (American Society for Microbiology, 2012)   Artículo / Artikulua  OpenAccess
      The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ...
    • Post-entry blockade of small ruminant lentiviruses by wild ruminants 

      Sanjosé, Leticia; Crespo, Helena Upna; Blatti-Cardinaux, Laure; Glaría Ezquer, Idoia Upna; Martínez Carrasco, Carlos; Berriatua, Eduardo; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna Orcid; Bertoni, Giuseppe; Reina Arias, Ramsés Upna Orcid (BioMed Central, 2016)   Artículo / Artikulua  OpenAccess
      Small ruminant lentivirus (SRLV) infection causes losses in the small ruminant industry due to reduced animal production and increased replacement rates. Infection of wild ruminants in close contact with infected domestic ...
    • Replication of small ruminant lentiviruses in aluminum hydroxide-induced granulomas in sheep: a potential new factor for viral dissemination 

      Echeverría Garín, Irache Upna Orcid; Miguel, Ricardo de; Asín, Javier; Rodríguez Largo, Ana; Fernández, Antonio; Pérez, Marta María; Andrés Cara, Damián de Upna Orcid; Luján, Lluís; Reina Arias, Ramsés Upna Orcid (American Society for Microbiology, 2021)   Artículo / Artikulua  OpenAccess
      Aluminum (Al)-based salts are widely used adjuvants in ruminants and other species to strengthen the immune response elicited against vaccine antigen(s). However, they can lead to the formation of long-lasting granulomas ...
    • Small ruminant lentiviruses: genetic variability, tropism and diagnosis 

      Ramírez, Hugo Upna Orcid; Reina Arias, Ramsés Upna Orcid; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna Orcid; Martínez, Humberto A. (MDPI, 2013)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV) cause a multisystemic chronic disease affecting animal production and welfare. SRLV infections are spread across the world with the exception of Iceland. Success in controlling SRLV spread ...
    • Small ruminant macrophage polarization may play a pivotal role on lentiviral infection 

      Crespo, Helena Upna; Bertolotti, Luigi; Juganaru, Magda; Glaría Ezquer, Idoia Upna; Andrés Cara, Damián de Upna Orcid; Amorena Zabalza, Beatriz Upna; Rosati, Sergio; Reina Arias, Ramsés Upna Orcid (BioMed Central, 2013)   Artículo / Artikulua  OpenAccess
      Small ruminant lentiviruses (SRLV) infect the monocyte/macrophage lineage inducing a long-lasting infection affecting body condition, production and welfare of sheep and goats all over the world. Macrophages play a pivotal ...
    • Study of compartmentalization in the visna clinical form of small ruminant lentivirus infection in sheep 

      Ramírez, Hugo Upna Orcid; Reina Arias, Ramsés Upna Orcid; Bertolotti, Luigi; Cenoz, Amaia Upna; Hernández, Mirna Margarita; San Román Aberasturi, Beatriz Upna Orcid; Glaría Ezquer, Idoia Upna; Andrés, Ximena de; Crespo, Helena Upna; Jauregui, Paula; Benavides, Julio; Polledo, Laura; Pérez, Valentín; García Marín, Juan F.; Rosati, Sergio; Amorena Zabalza, Beatriz Upna; Andrés Cara, Damián de Upna Orcid (BioMed Central, 2012)   Artículo / Artikulua  OpenAccess
      Background: A central nervous system (CNS) disease outbreak caused by small ruminant lentiviruses (SRLV) has triggered interest in Spain due to the rapid onset of clinical signs and relevant production losses. In a previous ...
    • Viral load, tissue distribution and histopathological lesions in goats naturally and experimentally infected with the Small Ruminant Lentivirus Genotype E (subtype E1 Roccaverano strain) 

      Grego, E.; Reina Arias, Ramsés Upna Orcid; Lanfredini, S.; Tursi, M.; Favole, A. (Elsevier, 2018)   Artículo / Artikulua  OpenAccess
      Small Ruminant Lentivirus (SRLV) subtype E1, also known as Roccaverano strain, is considered a low pathogenic virus on the basis of natural genetic deletions, in vitro properties and on-farm observations. In order to gain ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
      Logo MinisterioLogo Fecyt