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dc.creatorAlfonso Ruiz, Leopoldoes_ES
dc.creatorParada, Analiaes_ES
dc.creatorLegarra, Andréses_ES
dc.creatorUgarte, Evaes_ES
dc.creatorArana Navarro, Anaes_ES
dc.identifier.issn0999-193X (print)
dc.identifier.issn1297-9686 (electronic)
dc.description.abstractBreeding sheep populations for scrapie resistance could result in a loss of genetic variability. In this study, the effect on genetic variability of selection for increasing the ARR allele frequency was estimated in the Latxa breed. Two sources of information were used, pedigree and genetic polymorphisms (fifteen microsatellites). The results based on the genealogical information were conditioned by a low pedigree completeness level that revealed the interest of also using the information provided by the molecular markers. The overall results suggest that no great negative effect on genetic variability can be expected in the short time in the population analysed by selection of only ARR/ARR males. The estimated average relationship of ARR/ARR males with reproductive females was similar to that of all available males whatever its genotype: 0.010 vs. 0.012 for a genealogical relationship and 0.257 vs. 0.296 for molecular coancestry, respectively. However, selection of only ARR/ARR males implied important losses in founder animals (87 percent) and low frequency alleles (30 percent) in the ram population. The evaluation of mild selection strategies against scrapie susceptibility based on the use of some ARR heterozygous males was difficult because the genetic relationships estimated among animals differed when pedigree or molecular information was used, and the use of more molecular markers should be evaluated.en
dc.description.sponsorshipFinancial support for this work was provided by the Spanish “Ministerio de Ciencia y Tecnología” (EET2001-4891-C03-3)en
dc.publisherEDP Sciencesen
dc.relation.ispartofGenetics Selection Evolution, 2006, 38 (5). Págs. 495-511en
dc.rights© Inra, EDP Sciences, 2006en
dc.subjectGenetic variabilityen
dc.subjectLatxa sheepen
dc.subjectMolecular coancestry informationen
dc.subjectMicrosatellite analysisen
dc.subjectComputer programen
dc.subjectSpanish sheepen
dc.titleThe effects of selective breeding against scrapie susceptibility on the genetic variability of the latxa black-faced sheep breeden
dc.typeArtículo / Artikuluaes
dc.contributor.departmentProducción Agrariaes_ES
dc.contributor.departmentNekazaritza Ekoizpenaeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.type.versionVersión aceptada / Onetsi den bertsioaes

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