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Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis
dc.creator | Faus, Isabel | es_ES |
dc.creator | Zabalza Aznárez, Ana | es_ES |
dc.creator | Santiago, Julia | es_ES |
dc.creator | Nebauer, Sergio G. | es_ES |
dc.creator | Royuela Hernando, Mercedes | es_ES |
dc.creator | Serrano, Ramón | es_ES |
dc.creator | Gadea, José | es_ES |
dc.date.accessioned | 2015-10-27T08:36:35Z | |
dc.date.available | 2015-10-27T08:36:35Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1471-2229 | |
dc.identifier.uri | https://hdl.handle.net/2454/18633 | |
dc.description | Incluye 7 ficheros de datos | es_ES |
dc.description.abstract | Background: The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture. The molecular components involved in the cellular toxicity response to this herbicide at the expression level are still unidentified. Results: In this study, we identify the protein kinase GCN2 as a cellular component that fosters the action of glyphosate in the model plant Arabidopsis thaliana. Comparative studies using wild-type and gcn2 knock-out mutant seedlings show that the molecular programme that the plant deploys after the treatment with the herbicide, is compromised in gcn2. Moreover, gcn2 adult plants show a lower inhibition of photosynthesis, and both seedlings and adult gcn2 plants accumulate less shikimic acid than wild-type after treatment with glyphosate. Conclusions: These results points to an unknown GCN2-dependent factor involved in the cascade of events triggered by glyphosate in plants. Data suggest either that the herbicide does not equally reach the target-enzyme in a gcn2 background, or that a decreased flux in the shikimate pathway in a gcn2 plants minimize the impact of enzyme inhibition. | en |
dc.description.sponsorship | This work was mainly supported by the Universidad Politecnica de Valencia (PAID2011-16) and the Ministerio Español de Ciencia y Tecnología (BFU2011-22526). The work was partially supported through a grant from the Ministerio Español de Ciencia y Tecnología (AGL-2010-18621). | en |
dc.format.mimetype | application/pdf | en |
dc.format.mimetype | application/zip | en |
dc.language.iso | eng | en |
dc.publisher | BioMed Central | en |
dc.relation.ispartof | BMC Plant Biology 2015, 15:14 | en |
dc.rights | © 2015 Faus et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | |
dc.subject | Glyphosate | en |
dc.subject | GCN2 | en |
dc.subject | Transcriptomic | en |
dc.subject | Shikimate | en |
dc.subject | Translation | en |
dc.subject | Herbicides | en |
dc.subject | Horseweed conyza-canadensis | en |
dc.subject | Sugar-beet leaves | en |
dc.subject | Herbicide resistance | en |
dc.subject | Vacuolar sequestration | en |
dc.subject | Phosphate transporter | en |
dc.subject | Gene expression | en |
dc.subject | Thaliana | en |
dc.subject | Stress | en |
dc.subject | EIF2-alpha | en |
dc.subject | Wheat | en |
dc.title | Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | Artículo / Artikulua | es |
dc.contributor.department | Ciencias del Medio Natural | es_ES |
dc.contributor.department | Natura Ingurunearen Zientziak | eu |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.identifier.doi | 10.1186/s12870-014-0378-0 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2011-22526/ES/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//AGL2010-18621/ES/ | en |
dc.relation.publisherversion | https://dx.doi.org/10.1186/s12870-014-0378-0 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
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La licencia del ítem se describe como © 2015 Faus et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.