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Effects of exercise training on fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: a systematic review and meta-analysis
dc.creator | Ramírez Vélez, Robinson | es_ES |
dc.creator | García Hermoso, Antonio | es_ES |
dc.creator | Hackney, Anthony C. | es_ES |
dc.creator | Izquierdo Redín, Mikel | es_ES |
dc.date.accessioned | 2019-07-31T12:27:01Z | |
dc.date.available | 2019-07-31T12:27:01Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1476-511X | |
dc.identifier.uri | https://hdl.handle.net/2454/33800 | |
dc.description.abstract | Background: elevated levels of fetuin-A are associated with increased risks of metabolic syndrome, type 2 diabetes and nonalcoholic fatty liver disease. This meta-analysis investigated whether exercise interventions can reduce fetuin-A in adults. Methods: we searched clinical trials that objectively assessed fetuin-A and included study arms with exercise intervention. The pre-intervention and post-intervention data were used for meta-analysis. The effect sizes were calculated as standardized mean differences or changes in fetuin-A and expressed as Hedges' g using random-effects models. Results: the overall Hedges' g for fetuin-A in all included interventions was - 0.640 (95%CI - 1.129 to - 0.151; n = 9), but this effect was not observed in obese (g = - 0.096; 95%CI, - 0.328 to 0.135) and type 2 diabetes/dysglycemia (g = - 0.56; 95%CI, - 1.348 to 0.236) individuals. Additionally, the random-effects meta-regression analysis showed that there was not a greater decrease in fetuin-A in individuals who achieved greater body mass index reductions (regression coefficient = 0.065; 95%CI, - 0.185 to 0.315). Conclusion: supervised exercise is associated with reductions in fetuin-A levels in adults and elderly. However, the results of the present meta-analysis should be interpreted with caution because of the variety of type of exercises and individual obesity related-disorders involve. Therefore, additional high-quality randomized controlled trials describing the effect of supervised exercise interventions on fetuin-A in adults are still needed. | en |
dc.format.extent | 11 p. | |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | BioMed Central | en |
dc.relation.ispartof | Lipids In Health And Disease, 18, Article number: 23 (2019) | en |
dc.rights | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en |
dc.rights.uri | http//creativecommons.org/licenses/by/4.0/ | |
dc.subject | Cardiovascular disease | en |
dc.subject | Exercise training | en |
dc.subject | Fetuin-a | en |
dc.subject | Meta-analysis | en |
dc.subject | Metabolic syndrome | en |
dc.subject | Obesity | en |
dc.subject | Systematic review | en |
dc.subject | Type 2 diabetes | en |
dc.title | Effects of exercise training on fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: a systematic review and meta-analysis | en |
dc.type | info:eu-repo/semantics/article | en |
dc.type | Artículo / Artikulua | es |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.identifier.doi | 10.1186/s12944-019-0962-2 | |
dc.relation.publisherversion | https://doi.org/10.1186/s12944-019-0962-2 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
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La licencia del ítem se describe como © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.