Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity
Fecha
2022Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
Impacto
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10.1111/apa.16456
Resumen
Aim: Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the
relationships of resting leptin and adiponectin with bone parameters and whether
high muscular fitness levels affect these relationships in children with overweight or
obesity.
Methods: This cross-sectional study took part from 2014 ...
[++]
Aim: Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the
relationships of resting leptin and adiponectin with bone parameters and whether
high muscular fitness levels affect these relationships in children with overweight or
obesity.
Methods: This cross-sectional study took part from 2014 to 2016 in Granada, Spain.
Participants were recruited from University Hospitals, and we also used advertisements in local media and school contacts in the city. Adipokines were analysed in
plasma. Muscular fitness was assessed by one repetition maximum in bench and leg
press tests. Dual-energy X-ray absorptiometry was used to measure bone parameters.
Results: We included 84 children (10.0 ± 1.2y; 63% boys) in this analysis. Leptin was
negatively associated with lumbar spine bone mineral content (β = −0.162, p = 0.053).No significant interaction was found for muscular fitness. Simple slope estimates suggested that children performing more than 133.3 kg in leg press test ameliorated the
negative association between leptin and lumbar spine bone mineral content.
Conclusion: Leptin levels were negatively associated with lumbar spine bone mineral
content in children with overweight or obesity. A high muscular fitness at the lower
body could counteract this association. [--]
Materias
Adipokines,
Bone,
Muscle strength,
Obesity,
Prepubertal
Editor
Wiley
Publicado en
Acta Paediatrica 2022;111:1966–1973
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
This study was mainly supported by grants from the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, DEP2017-91544-EXP and RYC-2011-09011), European Regional Development Fund (ERDF) of the European Commission (No 667302) and the Alicia Koplowitz Foundation. Additional funding was obtained from the Andalusian Operational Programme supported with ERDF (FEDER in Spanish, B-CTS-355-UGR18). Additional support was obtained from University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence, Unit of Excellence on Exercise and Health, the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (SOMM17/6107/UGR); the EXERNET Research Network on Exercise and Health in Special populations (DEP2005-00046/ACTI); and the HL-PIVOT network - Healthy Living for Pandemic Event Protection. Funding for open access charge: Universidad de Granada / CBUA.
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