Anti-inflammatory and chondroprotective effects induced by phenolic compounds from onion waste extracts in ATDC-5 chondrogenic cell line
Fecha
2022Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
Impacto
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10.3390/antiox11122381
Resumen
Osteoarthritis is a prevalent degenerative condition that is closely related to the destruction
and inflammation of cartilage. The high prevalence of this pathology exhorts researchers to search
for novel therapeutic approaches. Vegetable–fruit wastes have emerged as a promising origin of
anti-inflammatory and antioxidant compounds that, in some cases, may also exert chondroprotective
effects ...
[++]
Osteoarthritis is a prevalent degenerative condition that is closely related to the destruction
and inflammation of cartilage. The high prevalence of this pathology exhorts researchers to search
for novel therapeutic approaches. Vegetable–fruit wastes have emerged as a promising origin of
anti-inflammatory and antioxidant compounds that, in some cases, may also exert chondroprotective
effects. This study aims to decipher the potential of onion waste products in the inhibition of
molecular events involved in osteoarthritis. Onion extracts showed a high content of phenolic
compounds and antioxidant properties. Cytocompatibility was demonstrated in the chondrogenic
cell line ATDC-5, exerting viability percentages higher than 90% and a slight increase in the S
phase cycle cell. The induction of inflammation mediated by the lipopolysaccharide and onion
extracts’ treatment substantially inhibited molecular markers related to inflammation and cartilage
degradation, highlighting the promising application of onion extracts in biomedical approaches. The
in silico analyses suggested that the results could be attributed to protocatechuic, ellagic, and vanillic
acids’ greater cell membrane permeability. Our work provides distinctive information about the
possible application of waste onion extracts as functional components with anti-inflammatory and
chondroprotective characteristics in osteoarthritis. [--]
Materias
Allium cepa L. waste extracts,
Chondroprotective,
Circular economy,
Inflammation,
NF-κB,
Osteoarthritis,
ROS
Editor
MDPI
Publicado en
Antioxidants, 2022, 11(12), 1-14
Departamento
Universidad Pública de Navarra. Departamento de Ciencias /
Nafarroako Unibertsitate Publikoa. Zientziak Saila /
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. Institute for Advanced Materials and Mathematics - INAMAT2
Versión del editor
Entidades Financiadoras
This work was supported by the Grants: Proyectos en Salud AES 2021 (PI21/00911; ISCIII), CIBER-BBN, CIBEROBN, Ministerio de Ciencia e Innovación-Fondo Europeo de Desarrollo Regional (PID2019-104915RB-I00), Fondo Social Europeo-Gobierno de Aragón (B16_20R) and SUDOE (Redvalue, SOE1/PI/E0123). This research was also funded by European Union’s H2020 research and innovation program under Marie Sklodowska-Curie grant agreement number 801586. G.M. gratefully acknowledges the support from the Miguel Servet Program (MS19/00092; ISCIII). M.P. acknowledges the support from the Gobierno de Aragón fellowship (CUS/581/2020). O.G. is Staff Personnel (I3SNS Stable Researcher) of Xunta de Galicia (Servizo Galego de Saude (SERGAS)) through a research-staff contract (ISCIII)/SERGAS).