Lifetime cannabis use and cognition in patients with schizophrenia spectrum disorders and their unaffected siblings
Fecha
2013Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión aceptada / Onetsi den bertsioa
Impacto
|
10.1007/s00406-013-0404-5
Resumen
The relationship between cannabis and cognitive performance is controversial. While both acute
administration and long-term cannabis use impair cognitive
performance in healthy subjects, several studies have
shown improved cognitive outcomes in patients with memory performance. In the control group, cannabis use
per se did not predict cognitive performance; however,
when adding lifetime toba ...
[++]
The relationship between cannabis and cognitive performance is controversial. While both acute
administration and long-term cannabis use impair cognitive
performance in healthy subjects, several studies have
shown improved cognitive outcomes in patients with memory performance. In the control group, cannabis use
per se did not predict cognitive performance; however,
when adding lifetime tobacco use to the model, we found a
negative association between lifetime cannabis and tobacco
use and processing speed and social cognition performance. Moreover, a lower IQ associated with current
cannabis use predicted worse attentional performance in
the control group. The differential pattern of associations
between cannabis use and cognitive performance in
patients compared with siblings and controls can be
explained by the negative impact of illness on cognition.
schizophrenia spectrum disorders who use cannabis. The
aim of this study was to determine the relationship between
lifetime cannabis use, as assessed longitudinally over
10 years of follow-up in a sample of 42 patients and 35 of
their unaffected siblings, and current cognitive performance. Forty-two healthy control subjects were assessed at
follow-up with the same instruments. Stepwise linear
regression revealed a negative effect of longitudinal cannabis use on performance in a social cognition task in the
patient group. In the sibling group, lifetime cannabis use
had a negative effect on processing speed and declarative [--]
Materias
Schizophrenia spectrum disorders,
Cognition,
Cannabis,
Longitudinal
Editor
Springer
Publicado en
European Archives of Psychiatry and Clinical Neuroscience (2013) 263:643–653
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
This study was partly funded by “Plan Nacional sobre Drogas” (Grant 2008/I/030; Grant 2008/090), SAF2008-05674-C01-C02; Comissionat per a Universitats i Recerca del DIUE of the Generalitat de Catalunya (2009SGR827), the Department of Health of the Government of Navarra (Grant 55/2007) and the ‘Carlos III Health Institute’ (FEDER Funds) from the Spanish Ministry of Health (Grant 08/I/1026).