Executive functioning in schizophrenia spectrum disorder patients and their unaffected siblings: a ten-year follow-up study
Fecha
2013Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión aceptada / Onetsi den bertsioa
Impacto
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10.1016/j.schres.2012.11.026
Resumen
Executive dysfunction represents a core deficit that is associated with schizophrenia spectrum disorders (SSDs).
However, the longitudinal course of executive deficits in SSDs is still controversial.
The aim of this study was to examine the executive performance of 34 SSD patients in relation to 34 of their
unaffected siblings over a period of 10 years. Both groups completed psychopathological ...
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Executive dysfunction represents a core deficit that is associated with schizophrenia spectrum disorders (SSDs).
However, the longitudinal course of executive deficits in SSDs is still controversial.
The aim of this study was to examine the executive performance of 34 SSD patients in relation to 34 of their
unaffected siblings over a period of 10 years. Both groups completed psychopathological and executive
assessments. Thirteen healthy controls were assessed using the same instruments.
At baseline, the SSD patients differed significantly from siblings and controls in their performance on the Trail
Making Test-B (TMT-B) and the number of categories in which they succeeded in the Wisconsin Card Sorting
Test (WCST). They also differed significantly from the controls in the total number of errors in the WCST. The
siblings did not differ in executive functioning from the controls over the follow-up. Longitudinally, the patients demonstrated significant improvement only for the TMT-B. However, only 14.71% of the patients
showed reliable and clinically significant improvements for the TMT-B, and 8.82% made more errors on the
WCST at the follow-up evaluation. Less than 3% of the patients showed either improved or worse results
on the remaining measures of the WCST. A stabilisation pattern for the WCST was observed in the three
groups.
The patients performed worse than their siblings and controls on both executive tests. Some patients exhibited
significant improvements in the TMT-B over time, but this improvement was reliable and clinically significant for
less than 15% of the sample. Thus, we conclude that the patients exhibited stable impairments over time in the
executive functions assessed. [--]
Materias
Psychosis,
Schizophrenia spectrum disorders,
Executive function,
Siblings,
Longitudinal study
Editor
Elsevier
Publicado en
Schizophrenia Research 143 (2013) 291-296
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
This study was partly funded by the Plan Nacional Sobre Drogas (grant 2008/I/030),
the Department of Health of the Government of Navarra (grant 55/2007) and the
Ministerio de Ciencia e Innovación (grant SAF2008-05674-C03-02)