Gold nanoparticles capped with a novel titanium(iv)-containing polyoxomolybdate cluster: selective and enhanced bactericidal effect against Escherichia coli
Fecha
2024Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113987RB-I00/ES/
AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121405-I00/ES/
AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106687RJ-I00/ES/
AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-127265OB-C21/ES/
Gobierno de Navarra//PC091-092 FOREST2+
Impacto
|
10.1002/smll.202305169
Resumen
Bacterial infections are a public health threat of increasing concern in medical care systems; hence, the search for novel strategies to lower the use of antibiotics and their harmful effects becomes imperative. Herein, the antimicrobial performance of four polyoxometalate (POM)-stabilized gold nanoparticles (Au@POM) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as Gram ...
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Bacterial infections are a public health threat of increasing concern in medical care systems; hence, the search for novel strategies to lower the use of antibiotics and their harmful effects becomes imperative. Herein, the antimicrobial performance of four polyoxometalate (POM)-stabilized gold nanoparticles (Au@POM) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as Gram-negative and Gram-positive bacteria models, respectively, is studied. The bactericidal studies performed, both in planktonic and sessile forms, evidence the antimicrobial potential of these hybrid nanostructures with selectivity toward Gram-negative species. In particular, the Au@GeMoTi composite with the novel [Ti2(HGeMo7O28)2]10¿ POM capping ligand exhibits outstanding bactericidal efficiency with a minimum inhibitory concentration of just 3.12 µm for the E. coli strain, thus outperforming the other three Au@POM counterparts. GeMoTi represents the fourth example of a water-soluble TiIV-containing polyoxomolybdate, and among them, the first sandwich-type structure having heteroatoms in high-oxidation state. The evaluation of the bactericidal mechanisms of action points to the cell membrane hyperpolarization, disruption, and subsequent nucleotide leakage and the low cytotoxicity exerted on five different cell lines at antimicrobial doses demonstrates the antibiotic-like character. These studies highlight the successful design and development of a new POM-based nanomaterial able to eradicate Gram-negative bacteria without damaging mammalian cells. [--]
Materias
Antimicrobial,
Cytotoxicity,
Escherichia coli,
Gold nanoparticles,
Pathogenic bacteria,
Polyoxometalates
Editor
Wiley
Publicado en
Small, 20(6), 2024, 2305169
Departamento
Universidad Pública de Navarra. Departamento de Ciencias /
Nafarroako Unibertsitate Publikoa. Zientziak Saila /
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. Institute for Advanced Materials and Mathematics - INAMAT2
Versión del editor
Entidades Financiadoras
The authors thank the following institutions for the financial support to carry out this research: Spanish Ministerio de Ciencia e Innovación,Spanish Agencia Estatal de Investigación, and FEDER “una manera dehacer Europa” (grant numbers PID2020-113987RB-I00, PDC2021-121405-I00, PID2019-106687RJ-I00, and PID2021-127265OB-C21); Gobierno de Navarra (grant number PC091-092 FOREST2+). CIBER-BBN is an initia-tive funded by the VI National R&D&i Plan 2008–2011 financed by the In-stituto de Salud Carlos III with the assistance of the European Regional Development Fund. M.P. acknowledges the support from Gobierno de Aragón (Orden CUS/581/2020). G.M. gratefully acknowledges the sup-port from the Miguel Servet Program (MS19/00092; Instituto de SaludCarlos III). Open access funding is provided by Universidad Pública de Navarra.
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