Influence of social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis
Fecha
2020Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Identificador del proyecto
Impacto
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10.1017/S0033291719002794
Resumen
Background. Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the direction of their associations is not clear. Therefore, the main aim of this s ...
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Background. Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the direction of their associations is not clear. Therefore, the main aim of this study was to analyze the influence of social cognition as a mediator between cognitive reserve and cognitive domains on functioning in FEP both at baseline and at 2 years. Methods The sample of the study was composed of 282 FEP patients followed up for 2 years. To analyze whether social cognition mediates the influence of cognitive reserve and cognitive domains on functioning, a path analysis was performed. The statistical significance of any mediation effects was evaluated by bootstrap analysis. Results. At baseline, as neither cognitive reserve nor the cognitive domains studied were related to functioning, the conditions for mediation were not satisfied. Nevertheless, at 2 years of follow-up, social cognition acted as a mediator between cognitive reserve and functioning. Likewise, social cognition was a mediator between verbal memory and functional outcome. The results of the bootstrap analysis confirmed these significant mediations (95% bootstrapped CI (—10.215 to —0.337) and (—4.731 to —0.605) respectively). Conclusions. Cognitive reserve and neurocognition are related to functioning, and social cognition mediates in this relationship. [--]
Materias
Cognitive reserve,
First episode psychosis,
Psychosocial functioning,
Social cognition
Editor
Cambridge University Press
Publicado en
Psychological Medicine, 50(16)
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila
Versión del editor
Entidades Financiadoras
This work was supported by the Carlos III Institute of
Health and European Fund for Regional Development (PI08/1213, PI11/
01977, PI14/01900, PI08/01026, PI11/02831, PI14/01621, PI08/1161, PI16/
00359, PI16/01164, PI18/00805), the Basque Foundation for Health Innovation
and Research (BIOEF), the Secretaria d´Universitats I Recerca del
Departament d´Economia I Coneixement (2017 SGR 1365), and R&D activities
in Biomedicine, Madrid Regional Government and Structural Funds of the
European Union (S2017/BMD-3740 (AGES-CM 2-CM)).