Artículos de revista DCS - OZS Aldizkari artikuluak: Envíos recientes
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Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences
Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal of introns and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that ... -
Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach
Background: Diabetes mellitus (DM) accelerates the progression of aortic stenosis (AS), but how their underlying molecular mechanisms interact is not clear. Moreover, whether DM contributes to clinically relevant sex-differences ... -
Intra-assessment resting metabolic rate variability is associated with cardiometabolic risk factors in middle-aged adults
The intra-assessment resting metabolic rate variability is related to cardiometabolic health, as suggested by previous literature. We studied whether that variability (expressed as coefficient of variation [CV; %]) for ... -
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway ... -
Impaired LXRα phosphorylation attenuates progression of fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation. How fat-rich diets promote progression from fatty liver to more damaging inflammatory and fibrotic stages is poorly understood. ... -
Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer
Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the ... -
20-Year trajectories of six psychopathological dimensions in patients with first-episode psychosis: could they be predicted?
(Elsevier, 2024) Artículo / ArtikuluaPatients with first-episode psychoses (FEP) exhibit heterogeneity in clinical manifestations and outcomes. This study investigated the long-term trajectories of six key psychopathological dimensions (reality-distortion, ... -
Sex-specific dose-response effects of a 24-week supervised concurrent exercise intervention on cardiorespiratory fitness and muscular strength in young adults: The ACTIBATE randomized controlled trial
Concurrent training has been postulated as an appropriate time-efficient strategy to improve physical fitness, yet whether the exercise-induced adaptations are similar in men and women is unknown. An unblinded randomized ... -
Evaluation of physical fitness in track and field throwing athletes across different competitive levels
A comprehensive understanding of physical fitness across different competitive levels is essential in track and field athletics. Coaches of throwers typically develop training regimens tailored to either performance ... -
Isolation of Lactic Acid Bacteria (LAB) from salmonids for potential use as probiotics: in vitro assays and toxicity assessment of salmo trutta embryonated eggs
This research investigates the potential of lactic acid bacteria (LAB) from freshwater salmonids as prospective probiotics for application in aquaculture. LAB and pathogenic bacteria were obtained from mucus and tissues ... -
Intentos de suicidio en personas mayores en servicios de urgencias psiquiátricas
FUNDAMENTOS. En las personas mayores hay una alta prevalencia de trastorno mental, baja demanda asistencial y mayor riesgo de conducta suicida. La atención en Urgencias psiquiátricas puede ser la puerta de acceso a los ... -
Effect of polygenic risk score, family load of schizophrenia and exposome risk score, and their interactions, on the long-term outcome of first-episode psychosis
Background. Consistent evidence supports the involvement of genetic and environmental factors, and their interactions, in the etiology of psychosis. First-episode psychosis (FEP) comprises a group of disorders that show ... -
El comienzo de la lactancia: experiencias de madres primerizas
Fundamento. La lactancia materna es importante para promover el desarrollo saludable del recién nacido. A pesar de sus beneficios, el abandono es masivo durante el primer trimestre de vida. El objetivo de esta investigación ... -
Health professionals' personal behaviours hindering health promotion: a study of nurses who smoke
Aim: To explore the views of current and ex-smoker nurses on their role in sup-porting patients to stop smoking. Background: Long-term conditions are closely linked to harmful lifestyle behaviours, including smoking and ... -
Los retos de la promoción de la salud en una sociedad multicultural: revisión narrativa de la literatura
La realidad multicultural en la que vivimos hoy en día, hace que los profesionales de la salud interactúen a diario con personas y familias de culturas diversas. La interacción entre una persona o familia y un profesional ... -
Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies
Background: Previous studies have shown that functional systemic immunity is required for the efficacy of PD-1/PD-L1 blockade immunotherapies in cancer. Hence, systemic reprogramming of immunosuppressive dysfunctional ... -
Baseline circulating blood cell counts and ratios and changes therein for predicting immune-related adverse events during immune checkpoint inhibitor therapy: a multicenter, prospective, observational, pan-cancer cohort study with a gender perspective
Several factors have been associated with the occurrence of immune-related adverse events (irAEs) induced by immune checkpoint inhibitor (ICI) therapy. Despite their availability, the predictive value of circulating blood ... -
Volunteerism as adolescent health promotion asset: a scoping review
The Aim of this scoping review was to explore the available literature on volunteerism in adolescence and the benefits that this activity may report in their healthy development, from a salutogenic perspective. Searches ... -
"Missed nursing care" in health promotion: raising awareness
Aim(s): This commentary aims to raise awareness of the possible causes of “missed nursing care” in health promotion and to propose possible solutions. Background: Although health promotion is an essential function of nursing ... -
The CRIAA Program complex intervention in primary care to support women and their families in breastfeeding: study protocol for a pilot trial
Aim: To report a pilot study protocol to assess the feasibility of a complex intervention, in the primary healthcare context, to support women and their families in breastfeeding. Design: A pilot/feasibility trial with ...