Modeling the flow and mass transport in a mechanically stimulated parametric porous scaffold under fluid-structure interaction approach
Fecha
2018Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión aceptada / Onetsi den bertsioa
Identificador del proyecto
Impacto
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10.1016/j.icheatmasstransfer.2018.05.014
Resumen
Tissue engineering scaffolds combined with bioreactors are used to cultivate cells with
the aim of reproducing tissues and organs. The cultivating process is critical due to
the delicate in-vitro environment in which the cells should reproduce. The distribu-
tion of nutrients within the engineered construct depend on the scaffold morphology
and the analysis of the fluid flow and transport phe ...
[++]
Tissue engineering scaffolds combined with bioreactors are used to cultivate cells with
the aim of reproducing tissues and organs. The cultivating process is critical due to
the delicate in-vitro environment in which the cells should reproduce. The distribu-
tion of nutrients within the engineered construct depend on the scaffold morphology
and the analysis of the fluid flow and transport phenomena under mechanical loading
when the scaffold is coupled with a bioreactor is crucial for this scope. Unfortunately,
due to the complicated microstructure of the scaffold, it is not possible to perform
this analysis with experiments and numerical simulation can help in this sense. In
this study we have computed the fluid flow and the mass transport of a parametrized
scaffold in perfusion bioreactors analyzing the influence of the microstructure of the
scaffold using the fluid-structure interaction approach. The latter allows considering
the porous construct as compliant yet determining important structural parameters
such as stresses and strains that could be sensed by the cells. The presented model
considered flow perfusion that provided nutrients and mechanical compression. In
particular, we have studied the effect of controllable parameters such as the diam-
eter of the scaffold strand and the porosity on the mechanical stresses and strains,
shear stress and mass transport. The results of this work will help to shed light on
the necessary microenvironment surrounding the cultivated cells improving culturing
scaffold fabrication. [--]
Materias
Scaffold,
Mass transfer,
Bioreactor,
Tissue engineering,
Mechanical stimulation,
Fluid-structure interaction
Editor
Elsevier
Publicado en
International Communications in Heat and Mass Transfer 96 (2018) 53-60
Departamento
Universidad Pública de Navarra. Departamento de Ingeniería /
Nafarroako Unibertsitate Publikoa. Ingeniaritza Saila
Versión del editor
Entidades Financiadoras
The authors acknowledge the financial supports to this project from the Spanish Ministry of Education, Culture and Sport via the National Program“Salvador de Madariaga”(PRX17/00335) and the Saskatchewan Health Research Foundation via the Health Research Group Program (SHRF Reference #2784). Also, the authors thank the CIBER-BBN financed by the Instituto de Salud Carlos III and the Spanish Ministry of Education, Industry and Competitiveness via the research project (DP12017-83259-R).