• Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus 

      Cucarella, Carme; Tormo Más, María Ángeles; Ubeda, Carles; Trotonda, María Pilar; Monzon, Marta; Peris, Cristòfol; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna Orcid; Penadés, José R. (American Society for Microbiology, 2004)   Artículo / Artikulua  OpenAccess
      Staphylococcus aureus is a common cause of intramammary infections, which frequently become chronic, associated with the ability of the bacteria to produce biofilm. Here, we report a relationship between the ability to ...
    • Role of sodium salicylate in Staphylococcus aureus quorum sensing, virulence, biofilm formation and antimicrobial susceptibility 

      Turner, Adam Benedict; Gerner, Erik; Firdaus, Rininta; Echeverz Sarasúa, Maite Upna Orcid; Werthén, María; Thomsen, Peter; Almqvist, Sofía; Trobos, Margarita (Frontiers Media, 2022)   Artículo / Artikulua  OpenAccess
      The widespread threat of antibiotic resistance requires new treatment options. Disrupting bacterial communication, quorum sensing (QS), has the potential to reduce pathogenesis by decreasing bacterial virulence. The aim ...
    • SarA positively controls Bap-dependent biofilm formation in Staphylococcus aureus 

      Trotonda, María Pilar; Manna, Adhar C.; Cheung, Ambrose L.; Lasa Uzcudun, Íñigo Upna Orcid; Penadés, José R. (American Society for Microbiology, 2005)   Artículo / Artikulua  OpenAccess
      The biofilm-associated protein Bap is a staphylococcal surface protein involved in biofilm formation. We investigated the influence of the global regulatory locus sarA on bap expression and Bap-dependent biofilm formation ...
    • Sensory deprivation in Staphylococcus aureus 

      Villanueva San Martín, Maite Upna Orcid; García Martínez, Begoña Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Rapún Araiz, Beatriz Upna Orcid; Ruiz de los Mozos Aliaga, Igor Upna; Solano Goñi, Cristina Upna Orcid; Martí, Miguel; Penadés, José R.; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Springer Nature, 2018)   Artículo / Artikulua  OpenAccess
      Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show ...
    • Staphylococcal Bap proteins build amyloid scaffold biofilm matrices in response to environmental signals 

      Taglialegna, Agustina Upna; Navarro, Susanna; Ventura, Salvador; Garnett, James A.; Matthews, Steve; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (Public Library of Science, 2016)   Artículo / Artikulua  OpenAccess
      Major components of the biofilm matrix scaffold are proteins that assemble to create a unified structure that maintain bacteria attached to each other and to surfaces. We provide evidence that a surface protein present in ...
    • Staphylococcus aureus develops an alternative, ica-independent biofilm in the absence of the arlRS two-component system 

      Toledo Arana, Alejandro Upna Orcid; Merino, Nekane Upna; Vergara Irigaray, Marta Upna; Débarbouillé, Michel; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2005)   Artículo / Artikulua  OpenAccess
      The biofilm formation capacity of Staphylococcus aureus clinical isolates is considered an important virulence factor for the establishment of chronic infections. Environmental conditions affect the biofilm formation capacity ...
    • Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins 

      Tormo Más, María Ángeles; Ferrer, María Desamparados; Maiques, Elisa; Ubeda, Carles; Selva, Laura; Lasa Uzcudun, Íñigo Upna Orcid; Calvete, Juan J.; Novick, Richard P.; Penadés, José R. (American Society for Microbiology, 2008)   Artículo / Artikulua  OpenAccess
      Staphylococcus aureus pathogenicity islands (SaPIs) have an intimate relationship with temperate staphylococcal phages. During phage growth, SaPIs are induced to replicate and are efficiently encapsidated into special small ...
    • Staphylococcus aureus susceptibility to complestatin and corbomycin depends on the VraSR two-component system 

      Gómez Arrebola, Carmen Upna Orcid; Hernández, Sara B.; Culp, Elizabeth J.; Wright, Gerard D.; Solano Goñi, Cristina Upna Orcid; Cava, Felipe; Lasa Uzcudun, Íñigo (American Society for Microbiology, 2023)   Artículo / Artikulua  OpenAccess
      The overuse of antibiotics in humans and livestock has driven the emergence and spread of antimicrobial resistance and has therefore prompted research on the discovery of novel antibiotics. Complestatin (Cm) and corbomycin ...
    • Study of the molecular mechanisms underlying Bap-mediated cell-cell interactions in Staphylococcus aureus 

      Taglialegna, Agustina Upna (2016)   Tesis doctoral / Doktoretza tesia  OpenAccess
      La mayoría de los microorganismos son capaces de vivir en comunidades sésiles, siendo esta forma de crecimiento bastante más frecuente que la forma de vida planctónica. En estas comunidades microbianas, conocidas como ...
    • A systematic evaluation of the two-component systems network reveals that ArlRS is a key regulator of catheter colonization by Staphylococcus aureus 

      Burgui Erice, Saioa Upna Orcid; Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (Frontiers Media, 2018)   Artículo / Artikulua  OpenAccess
      Two-component systems (TCS) are modular signal transduction pathways that allow cells to adapt to prevailing environmental conditions by modifying cellular physiology. Staphylococcus aureus has 16 TCSs to adapt to the ...
    • Systematic reconstruction of the complete two-component sensorial network in staphylococcus aureus 

      Rapún Araiz, Beatriz Upna Orcid; Haag, Andreas F.; Gil Puig, Carmen Upna Orcid; Dorado Morales, Pedro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2020)   Artículo / Artikulua  OpenAccess
      In bacteria, adaptation to changes in the environment is mainly controlled through two-component signal transduction systems (TCSs). Most bacteria contain dozens of TCSs, each of them responsible for sensing a different ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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