• Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids 

      Matilla Cuenca, Leticia Upna Orcid; Gil Puig, Carmen Upna Orcid; Cuesta Ferre, Sergio; Rapún Araiz, Beatriz Upna Orcid; Mira, Alex; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Ziemité, Miglé (Nature Research, 2020)   Artículo / Artikulua  OpenAccess
      The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the ...
    • Bacterial biofilm functionalization through Bap amyloid engineering 

      Matilla Cuenca, Leticia Upna Orcid; Taglialegna, Agustina Upna; Gil Puig, Carmen Upna Orcid; Toledo Arana, Alejandro; Lasa Uzcudun, Íñigo; Valle Turrillas, Jaione Upna Orcid (Springer Nature, 2022)   Artículo / Artikulua  OpenAccess
      Biofilm engineering has emerged as a controllable way to fabricate living structures with programmable functionalities. The amyloidogenic proteins comprising the biofilms can be engineered to create self-assembling ...
    • A DIVA vaccine strain lacking RpoS and the secondary messenger c-di-GMP for protection against salmonellosis in pigs 

      Gil Puig, Carmen Upna Orcid; Latasa Osta, Cristina Upna; García Ona, Enrique Upna; Lázaro, Isidro; Labairu, Javier; Echeverz Sarasúa, Maite Upna Orcid; Burgui Erice, Saioa Upna Orcid; García Martínez, Begoña Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Solano Goñi, Cristina Upna Orcid (BioMed Central, 2020)   Artículo / Artikulua  OpenAccess
      Salmonellosis is the second most common food-borne zoonosis in the European Union, with pigs being a major reservoir of this pathogen. Salmonella control in pig production requires multiple measures amongst which vaccination ...
    • Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections 

      Prieto Mariscal, Juana María; Rapún Araiz, Beatriz Upna Orcid; Gil Puig, Carmen Upna Orcid; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid; Latasa Osta, Cristina Upna (Nature Research, 2020)   Artículo / Artikulua  OpenAccess
      Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS) that determines bacterial ...
    • A systematic evaluation of the two-component systems network reveals that ArlRS is a key regulator of catheter colonization by Staphylococcus aureus 

      Burgui Erice, Saioa Upna Orcid; Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (Frontiers Media, 2018)   Artículo / Artikulua  OpenAccess
      Two-component systems (TCS) are modular signal transduction pathways that allow cells to adapt to prevailing environmental conditions by modifying cellular physiology. Staphylococcus aureus has 16 TCSs to adapt to the ...
    • Systematic reconstruction of the complete two-component sensorial network in staphylococcus aureus 

      Rapún Araiz, Beatriz Upna Orcid; Haag, Andreas F.; Gil Puig, Carmen Upna Orcid; Dorado Morales, Pedro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2020)   Artículo / Artikulua  OpenAccess
      In bacteria, adaptation to changes in the environment is mainly controlled through two-component signal transduction systems (TCSs). Most bacteria contain dozens of TCSs, each of them responsible for sensing a different ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
      Logo MinisterioLogo Fecyt