Listar Dpto. Ciencias de la Salud - Osasun Zientziak Saila por autor UPNA "Goñi Irigoyen, Saioa"
Mostrando ítems 1-10 de 10
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Circulating low density neutrophils are associated with resistance to anti-PD1 immunotherapy in squamous head and neck cancer
Arrazubi, Virginia; Goñi Irigoyen, Saioa
; González Borja, Iranzu; Hernández García, Irene; Arasanz Esteban, Hugo; Pérez Sanz, Jairo; Bocanegra Gondán, Ana Isabel; Kochan, Grazyna; Escors Murugarren, David; Ruiz de Azúa, Yerani; Elizalde, Jesús María; Viúdez, Antonio; Vera García, Ruth (Wiley, 2023)
Artículo / Artikulua
Background: Identification of predictive biomarkers to Immune checkpoint inhibitors (ICIs) in head and neck cancer (HNSCC) is an unmet need. Methods: This was a prospective observational study including 25 patients with ... -
Cytokines and lymphoid populations as potential biomarkers in locally and borderline pancreatic adenocarcinoma
González Borja, Iranzu; Viúdez, Antonio; Alors-Pérez, Emilia; Goñi Irigoyen, Saioa ; Amat Villegas, Irene ; Ghanem, Ismael; Pazo-Cid, Roberto; Feliu, Jaime; Alonso, Laura; López López, Carlos; Arrazubi, Virginia; Gallego, Javier; Pérez Sanz, Jairo; Hernández García, Irene; Vera García, Ruth; Castaño, Justo P.; Fernández Irigoyen, Joaquín (MDPI, 2022)
Artículo / Artikulua 
Despite its relative low incidence, PDAC is one of the most aggressive and lethal types of cancer, being currently the seventh leading cause of cancer death worldwide, with a 5-year survival rate of 10.8%. Taking into ... -
Deciphering CHFR role in pancreatic ductal adenocarcinoma
González Borja, Iranzu; Alors-Pérez, Emilia; Amat Villegas, Irene; Alonso, Laura; Viyuela-García, Cristina; Goñi Irigoyen, Saioa ; Reyes, José C.; Ceballos-Chávez, María; Hernández García, Irene; Sánchez-Frías, Marina E.; Santamaría, Enrique; Razquin, Socorro; Arjona Sánchez, Álvaro; Arrazubi, Virginia; Pérez Sanz, Jairo; Vera García, Ruth; Fernández Irigoyen, Joaquín ; Castaño, Justo P.; Viúdez, Antonio (Frontiers Media, 2021)
Artículo / Artikulua
Checkpoint with forkhead-associated and ring finger domains (CHFR) has been proposed as a predictive and prognosis biomarker for different tumor types, but its role in pancreatic ductal adenocarcinoma (PDAC) remains unknown. ... -
Epidermal growth factor receptor ligands in murine models for erythropoietic protoporphyria: potential novel players in the progression of liver injury
Berasain, Carmen; Sampedro, Ana; Mauleón, I.; Goñi Irigoyen, Saioa ; Latasa, Maria Ujue; Matscheko, N.; García-Bravo, M.; Unzu, Carmen; Corrales, Fernando J.; Enríquez de Salamanca, R.; Prieto, Jesús; Ávila, Matías A.; Fontanellas, Antonio (Pergamon Press, 2009)
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Activation of the epidermal growth factor receptor (EGFR) plays an important role in liver regeneration and resistance to acute injury. However its chronic activation participates in the progression of liver disease, ... -
Epigenetic regulation of microRNAs in cancer: shortening the distance from bench to bedside
Pajares Villandiego, María Josefa ; Alemany Cosme, Ester; Goñi Irigoyen, Saioa ; Bandrés Elizalde, Eva ; Palanca Ballester, Cora; Sandoval, Juan (MDPI, 2021)
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Cancer is a complex disease involving alterations of multiple processes, with both genetic and epigenetic features contributing as core factors to the disease. In recent years, it has become evident that non-coding RNAs ... -
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
Liang, Ning; Damdimopoulos, Anastasius; Goñi Irigoyen, Saioa ; Huang, Zhiqiang; Vedin, Lise-Lotte; Jakobsson, Tomas; Giudici, Marco; Ahmed, Osman; Pedrelli, Matteo; Barilla, Serena; Alzaid, Fawaz; Mendoza, Arturo; Schröder, Tarja; Kuiper, Raoul; Parini, Paolo; Hollenberg, Anthony; Lefebvre, Philippe; Francque, Sven; Van Gaal, Luc; Staels, Bart; Venteclef, Nicolas; Treuter, Eckardt; Fan, Rongrong (Nature Research, 2019)
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Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway ... -
Impaired LXRα phosphorylation attenuates progression of fatty liver disease
Bécares, Natalia; Gage, Matthew C.; Voisin, Maud; Shrestha, Elina; Martín-Gutiérrez, Lucía; Liang, Ning; Louie, Rikah; Pourcet, Benoît; Pello, Óscar M.; Luong, Tu Vinh; Goñi Irigoyen, Saioa ; Pichardo-Almarza, César; Røberg-Larsen, Hanne; Díaz-Zuccarini, Vanessa; Steffensen, Knut R.; O’Brien, Alastair; Garabedian, Michael J.; Rombouts, Krista; Treuter, Eckardt; Pineda-Torra, Inés (Cell Press, 2019)
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Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation. How fat-rich diets promote progression from fatty liver to more damaging inflammatory and fibrotic stages is poorly understood. ... -
Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences
Berasain, Carmen; Goñi Irigoyen, Saioa ; Castillo, Josefa; Latasa, Maria Ujue; Prieto, Jesús; Ávila, Matías A. (Baishideng Publishing Group, 2010)
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Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal of introns and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that ... -
Omics approaches in pancreatic adenocarcinoma
González Borja, Iranzu; Viúdez, Antonio; Goñi Irigoyen, Saioa ; Santamaría, Enrique; Carrasco García, Estefanía; Pérez Sanz, Jairo; Hernández García, Irene (MDPI, 2019)
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Pancreatic ductal adenocarcinoma, which represents 80% of pancreatic cancers, is mainly diagnosed when treatment with curative intent is not possible. Consequently, the overall five-year survival rate is extremely dismal—around ... -
Pediococcus acidilactici pA1c® improves the beneficial effects of metformin treatment in type 2 diabetes by controlling glycaemia and modulating intestinal microbiota
Cabello Olmo, Miriam ; Oneca, María ; Urtasun Alonso, Raquel ; Pajares Villandiego, María Josefa ; Goñi Irigoyen, Saioa ; Riezu Boj, José I.; Milagro, F. I. ; Ayo, Josune; Encío Martínez, Ignacio ; Barajas Vélez, Miguel Ángel ; Araña Ciordia, Miriam (MDPI, 2023)
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Type 2 diabetes (T2D) is a complex metabolic disease, which involves maintained hyperglycemia, mainly due to the development of an insulin resistance process. Metformin administration is the most prescribed treatment for ...
