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Tackling the biological meaning of the human olfactory bulb dyshomeostatic proteome across neurological disorders: an integrative bioinformatic approach
(MDPI, 2021)
info:eu-repo/semantics/article,
Olfactory dysfunction is considered an early prodromal marker of many neurodegenerative diseases. Neuropathological changes and aberrant protein aggregates occur in the olfactory bulb (OB), triggering a tangled cascade of ...
Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism
(ACS Publications, 2020)
info:eu-repo/semantics/article,
The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining ...
Progressive modulation of the human olfactory bulb transcriptome during Alzheimer´s disease evolution: novel insights into the olfactory signaling across proteinopathies
(Impact Journals, 2017)
info:eu-repo/semantics/article,
Alzheimer´s disease (AD) is characterized by progressive dementia, initially
presenting olfactory dysfunction. Despite the olfactory bulb (OB) is the first central
structure of the olfactory pathway, we lack a complete ...