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Analysis of the association between polymorphisms in intergenic regions of Staphylococcus aureus genes involved in biofilm formation and periprosthetic joint infections
(2022)
info:eu-repo/semantics/doctoralThesis,
In this thesis, we have focused on studying variants found in IGRs adjacent to the most important genes involved in S. aureus biofilm formation; the icaADBCR locus, and the genes encoding the family of surface adhesins. ...
Role of sodium salicylate in Staphylococcus aureus quorum sensing, virulence, biofilm formation and antimicrobial susceptibility
(Frontiers Media, 2022)
Artículo / Artikulua,
The widespread threat of antibiotic resistance requires new treatment options. Disrupting bacterial communication, quorum sensing (QS), has the potential to reduce pathogenesis by decreasing bacterial virulence. The aim ...
Functional analysis of intergenic regulatory regions of genes encoding surface adhesins in Staphylococcus aureus isolates from periprosthetic joint infections
(Elsevier, 2022)
Artículo / Artikulua,
Staphylococcus aureus is a leading cause of prosthetic joint infections (PJI). Surface adhesins play an important
role in the primary attachment to plasma proteins that coat the surface of prosthetic devices after ...
Staphylococcus aureus susceptibility to complestatin and corbomycin depends on the VraSR two-component system
(American Society for Microbiology, 2023)
Artículo / Artikulua,
The overuse of antibiotics in humans and livestock has driven the emergence and spread of antimicrobial resistance and has therefore prompted research
on the discovery of novel antibiotics. Complestatin (Cm) and corbomycin ...
Bacterial biofilm functionalization through Bap amyloid engineering
(Springer Nature, 2022)
Artículo / Artikulua,
Biofilm engineering has emerged as a controllable way to fabricate living structures with programmable functionalities. The amyloidogenic proteins comprising the biofilms can be engineered to create self-assembling ...
lnsights into bacterial functional amyloids using the staphyiococcal Bap protein asan amyloid model
(2022)
info:eu-repo/semantics/doctoralThesis,
Los arniloides funcionales son componentes clave de la matriz del biofilrn de muchas bacterias. Estas estructuras proporcionan resistencia a las proteasas y a condiciones adversas de desnaturalización, y refuerzan y dan ...
Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections
(Nature Research, 2020)
Artículo / Artikulua,
Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the
aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS)
that determines bacterial ...
Novel strategies for treating biofilm and MRSA associated infections
(2021)
info:eu-repo/semantics/doctoralThesis,
En esta tesis hemos trabajado en dos estrategias, un cribado fenotípico y
otro frente a una diana específica, que podrían ayudar a ampliar las alternativas
terapéuticas frente a S. aureus. En el primer capítulo, nos hemos ...
Papel de los sistemas de dos componentes de Staphylococcus aureus en la susceptibilidad a complestatina y corbomicina y en la regulación génica en ausencia de fosforilación
(2022)
info:eu-repo/semantics/doctoralThesis,
Staphylococcus aureus es una bacteria versátil que se puede encontrar estableciendo una relación comensal en la piel de, aproximadamente, el 30% de la población sin causar ningún problema. Sin embargo, cuando ésta atraviesa ...
The role of ArlRS and VraSR in regulating ceftaroline hypersusceptibility in methicillin-resistant Staphylococcus aureus
(MDPI, 2021)
info:eu-repo/semantics/article,
Methicillin-resistant Staphylococcus aureus infections are a global health problem. New control strategies, including fifth-generation cephalosporins such as ceftaroline, have been developed, however rare sporadic resistance ...