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Deregulated transcription and proteostasis in adult mapt knockout mouse
(MDPI, 2023)
Artículo / Artikulua,
Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with ...
Improvement of cognitive function in wild-type and Alzheimer's disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells
(Frontiers Media, 2023)
Artículo / Artikulua,
A complex network of interactions exists between the olfactory, immune and central nervous systems. In this work we intend to investigate this connection through the use of an immunostimulatory odorant like menthol, analyzing ...
Proteostatic modulation in brain aging without associated Alzheimer's disease-and age-related neuropathological changes
(Impact Journals, 2023)
Artículo / Artikulua,
Aims: (Phospho)proteomics of old-aged subjects without cognitive or behavioral symptoms, and without ADneuropathological changes and lacking any other neurodegenerative alteration will increase understanding about
the ...
Biomarkers of delirium risk in older adults: a systematic review and meta-analysis
(Frontiers Media, 2023)
Artículo / Artikulua,
Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the ...
Metschnikowia pulcherrima as an efficient biocontrol agent of Botrytis cinerea infection in apples: unraveling protection mechanisms through yeast proteomics
(Elsevier, 2023)
Artículo / Artikulua,
The results obtained in this study show that the Mp-30 strain of Metschnikowia pulcherrima is able to completely
prevent Botrytis cinerea infection in apples, which is a major postharvest disease of fruits throughout the ...
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
(BMC, 2023)
Artículo / Artikulua,
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture ...
Stabilization of 14-3-3 protein-protein interactions with Fusicoccin-A decreases alpha-synuclein dependent cell-autonomous death in neuronal and mouse models
(Elsevier, 2023)
Artículo / Artikulua,
Synucleinopathies are a group of neurodegenerative diseases without effective treatment characterized by the abnormal aggregation of alpha-synuclein (aSyn) protein. Changes in levels or in the amino acid sequence of aSyn ...
Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior
(Life Science Alliance, 2023)
Artículo / Artikulua,
Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of ...
Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer
(Springer Nature, 2023)
Artículo / Artikulua,
Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the ...
The regulators of peroxisomal acyl-carnitine shuttle CROT and CRAT promote metastasis in melanoma
(Elsevier, 2023)
Artículo / Artikulua,
Circulating tumor cells are the key link between a primary tumor and distant metastases, but once in the
bloodstream, loss of adhesion induces cell death. To identify the mechanisms relevant for melanoma circulating
tumor ...